Engineering a Tumor-Acidity-Responsive PEG-Sheddable Nanoassembly for Combating Drug Resistance
文献类型： 外文期刊
作者： Xie, Jin 1 ; Zhou, Mengxue 3 ; Ren, Hongyu 3 ; Dou, Rui 3 ; Zhang, Jiayu 3 ; Hu, Yi 3 ; Ouyang, Jun 2 ; Chen, Jun 3 ;
作者机构： 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Biol Sample Bank, Zhengzhou 450052, Henan, Peoples R China
2.Southern Med Univ, Guangdong Engn Res Ctr Translat Med 3D Printing Ap, Natl Virtual & Real Expt Educ Ctr Med Morphol, Sch Basic Med Sci,Natl Key Discipline Human Anat,G, Guangzhou 510515, Peoples R China
3.Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
4.Univ Chinese Acad Sci UCAS, Chinese Acad Sci CAS, Beijing 100049, Peoples R China
5.Chinese Acad Agr Sci, Tea Res Inst, Key Lab Tea Biol & Resource Utilizat, Minist Agr, Hangzhou 310008, Peoples R China
6.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Biomed Engn Facil Natl Infrastruct Translat Med, Beijing 100730, Peoples R China
关键词： core-crosslinked micellar nanoassembly; co-delivery; drug resistance; nanomedicine; tumor-acidity-responsive
期刊名称：MACROMOLECULAR CHEMISTRY AND PHYSICS （ 影响因子：2.7； 五年影响因子：2.5 ）
ISSN： 1022-1352
年卷期： 2025 年 226 卷 13 期
页码：
收录情况： SCI
摘要： This study presents a simple strategy to develop a tumor-acidity responsive core-crosslinked micellar nanoassembly capable of delivering multiple drugs to combat drug resistance. Paclitaxel (PTX) nanocrystals are prepared using D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) as an emulsifier and cross-linked with poly(beta-cyclodextrin) (PCD) to form the core. An acid-labile prodrug, poly(ethylene glycol)-doxorubicin (mPEG-DOX), is utilized as the shell, forming a core-shell nanoassembly (CSNA) via supramolecular interactions. The CSNA demonstrated high stability in aqueous and serum environments, with triggered shell-detachment in response to tumor acidity. The nanomedicine exhibited superior inhibition of drug-resistant cancer cell line MCF-7/ADR compared to DOX or PTX alone, offering potential to overcome drug resistance in chemotherapy.
- 相关文献
作者其他论文 更多>>
-
Osmotic dehydration with different agents induced pectin diversity: Physicochemical and structural properties of pectin from instant controlled pressure drop dried peach chips
作者：Wang, Fengzhao;Bi, Jinfeng;Xie, Jin;Wang, Jingxuan;Lyu, Jian;Wang, Fengzhao;Bi, Jinfeng;Wang, Jingxuan
关键词：Osmotic dehydration; Pectin; Trehalose; Thermal stability; Rheological properties
-
Unlocking the coupling potential of built-in electric field and pulsed electroreduction for efficient nitrate to ammonia at low concentrations
作者：Wang, He;Chen, Kaiyi;Wei, Jiamin;Chen, Jun;Yang, Tinghai;Wang, He;Yan, Qun;Liu, Qiang;Yan, Qun
关键词：eNO3RA; Built-in electric field; Pulsed electroreduction; Low nitrate concentration; Sustainable nitrogen recycling
-
Somatic embryogenetic receptor kinase TaSERL2 regulates heat stress tolerance in wheat by influencing TaBZR2 protein stability and transcriptional activity
作者：Hao, Xiang-Yang;Fu, Yi-Han;Xu, Wei-Gang;Hao, Xiang-Yang;Peng, Chao-Jun;Fang, Yu-Hui;Li, Yan;Dong, Hai-Bin;Xu, Wei-Gang;Hao, Xiang-Yang;Yu, Tai-Fei;Xu, Zhao-Shi;Chen, Jun;Ma, You-Zhi;Hao, Xiang-Yang;Peng, Chao-Jun;Fang, Yu-Hui;Li, Yan;Dong, Hai-Bin;Xu, Wei-Gang
关键词：common wheat; TaBZR2; heat stress; interaction identification; signal transduction; negative regulation
-
EGCG and DOX dual-drug-loaded enzyme-responsive nanovesicles boost mitochondrial-mediated ICD for improved immunotherapy
作者：Zhou, Mengxue;Wang, Ying;Zhou, Chuang;Dai, Weidong;Lv, Haipeng;Lin, Zhi;Cui, Hongchun;Yu, Jizhong;Geng, Huan;Ruan, Lifo;Chen, Jun;Ruan, Lifo;Chen, Jun;Zhao, Yanni
关键词：MMP-2 sensitive nanovesicles; EGCG; tumor fibrosis; mitochondria-targeted; cancer immunotherapy
-
Advances and Future Perspectives of HER2 Mutations in Non-Small Lung Cancer (NSCLC), Especially in China
作者：Liu, Chang;Li, Tao;Lv, Yahui;Zhou, Xin;Yang, Fan;Dong, Yi;Li, Ruixin;Zhang, Fan;Hu, Yi;Liu, Chang;Li, Tao;Lv, Yahui;Zhou, Xin;Yang, Fan;Dong, Yi;Li, Ruixin;Zhang, Fan;Hu, Yi;Liu, Chang;Liu, Chang;Li, Tao;Cui, Xiaoran;Lv, Yahui;Liu, Min;Zhou, Xin;Yang, Fan;Dong, Yi;Li, Ruixin;Zhang, Fan;Zhang, Tong;Hu, Yi;Li, Tao;Zhang, Tong;Li, Tao;Cui, Xiaoran;Liu, Min
关键词：HER2; Non-small lung cancer (NSCLC); China
-
Spent Coffee Ground and Its Derivatives as Soil Amendments-Impact on Soil Health and Plant Production
作者：Hu, Yi;Li, Juan;Wu, Yiping;Hu, Yi;Li, Juan;Hu, Yi;Li, Juan;Zhang, Dongdong;Qi, Zhiyong;Yang, Rui
关键词：compost; vermicsompost; thermochemical conversion; biocontrol; biofertilizer
-
Mechanism of action and future perspectives of ADCs in combination with immune checkpoint inhibitors for solid tumors
作者：Lv, Yahui;Li, Tao;Liu, Chang;Wang, An;Wang, Ting;Zhou, Xin;Li, Ruixin;Zhang, Fan;Hu, Yi;Liu, Zhefeng;Lv, Yahui;Lv, Yahui;Cui, Xiaoran;Li, Tao;Liu, Chang;Wang, An;Wang, Ting;Zhou, Xin;Li, Ruixin;Zhang, Fan;Hu, Yi;Zhang, Tong;Liu, Zhefeng;Cui, Xiaoran;Li, Tao;Zhang, Tong;Li, Tao;Liu, Zhefeng;Liu, Chang;Wang, Ting
关键词：Antibody-drug conjugates; Immunotherapy; Immune checkpoint inhibitors; Solid tumor
