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LncRNA GTL2 regulates myoblast proliferation and differentiation via the PKA-CREB pathway in Duolang sheep

文献类型： 外文期刊

作者： Chen, Qian 1 ; Bao, Jing-Jing 1 ; Zhang, He-Chun 2 ; Huang, Chang 1 ; Zhao, Qian 1 ; Pu, Ya-Bin 1 ; Jiang, Lin 1 ; Hosseiny, Adel 3 ; Ibrahim, Muhammad 3 ; Hussain, Tanveer 4 ; He, Xiao-Hong 1 ; Ma, Yue-Hui 1 ; Zhao, Qian-Jun 1 ;

作者机构： 1.Chinese Acad Agr Sci CAAS, Inst Anim Sci, Beijing 100193, Peoples R China

2.Chaoyang Chaomu Breeding Farm Co Ltd, Chaoyang 122629, Liaoning, Peoples R China

3.Desert Res Ctr, Dept Anim Breeding, Cairo 11435, Egypt

4.Virtual Univ Pakistan, Dept Biol Sci, Lahore 54000, Pakistan

关键词： Skeletal muscle; LncRNA; Skeletal muscle satellite cells; Sheep; PKA-CREB pathway

期刊名称：ZOOLOGICAL RESEARCH （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 2095-8137

年卷期： 2024 年 45 卷 6 期

页码：

收录情况： SCI

摘要： Long non-coding RNAs (lncRNAs), which are RNA molecules longer than 200 nucleotides that do not encode proteins, are implicated in a variety of biological processes, including growth and development. Despite research into the role of lncRNAs in skeletal muscle development, the regulatory mechanisms governing ovine skeletal muscle development remain unclear. In this study, we analyzed the expression profiles of lncRNAs in skeletal muscle from 90-day-old embryos (F90), 1-month-old lambs (L30), and 3-year-old adult sheep (A3Y) using RNA sequencing. In total, 4 738 lncRNAs were identified, including 997 that were differentially expressed. Short-time series expression miner analysis identified eight significant expression profiles and a subset of lncRNAs potentially involved in muscle development. Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that the predicted target genes of these lncRNAs were primarily enriched in pathways associated with muscle development, such as the cAMP and Wnt signaling pathways. Notably, the expression of lncRNA GTL2 was found to decrease during muscle development. Moreover, GTL2 was highly expressed during the differentiation of skeletal muscle satellite cells (SCs) and was shown to modulate ovine myogenesis by affecting the phosphorylation levels of PKA and CREB. Additionally, GTL2 was found to regulate both the proliferation and differentiation of SCs via the PKACREB signaling pathway. Overall, this study provides a valuable resource and offers novel insights into the functional roles and regulatory mechanisms of lncRNAs in ovine skeletal muscle growth and development.

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