文献类型： 外文期刊
作者： Chen, Qian 1 ; Zhu, Li 6 ; Zhang, Sufen 7 ; Qiao, Shuai 1 ; Ding, Zhong Jie 8 ; Zheng, Shao Jian 8 ; Guo, Jiangtao 3 ; Su, Nannan 1 ;
作者机构： 1.Zhejiang Univ, Affiliated Hosp 4, Ctr Membrane Receptors & Brain Med, Sch Med, Yiwu 322000, Zhejiang, Peoples R China
2.Zhejiang Univ, Int Inst Med, Int Sch Med, Yiwu 322000, Zhejiang, Peoples R China
3.Zhejiang Univ, Affiliated Hosp 4, Sch Med, Dept Biophys, Hangzhou 310058, Zhejiang, Peoples R China
4.Zhejiang Univ, Affiliated Hosp 4, Sch Med, Dept Neurol, Hangzhou 310058, Zhejiang, Peoples R China
5.Nanhu Brain Comp Interface Inst, Hangzhou 311100, Zhejiang, Peoples R China
6.Chinese Acad Agr Sci, Tea Res Inst, 9 Meiling South Rd, Hangzhou 310008, Zhejiang, Peoples R China
7.Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou 310058, Zhejiang, Peoples R China
8.Zhejiang Univ, Coll Life Sci, State Key Lab Plant Environm Resilience, Hangzhou 310058, Zhejiang, Peoples R China
期刊名称：STRUCTURE （ 影响因子：4.3； 五年影响因子：4.5 ）
ISSN： 0969-2126
年卷期： 2025 年 33 卷 5 期
页码：
收录情况： SCI
摘要： The Arabidopsis thaliana auxin transporter ABCB1 plays a fundamental role in the regulation of plant growth and development. While its homolog ABCB19 was previously shown to transport brassinosteroids (BR), another class of essential hormones, the ability of ABCB1 to mediate BR transport has remained unexplored. In this study we show that ABCB1 also transports brassinosteroids with an in vitro brassinolide (BL) transport assay. Using single-particle cryo-electron microscopy, we determined ABCB1 structures in multiple inward-facing conformations in the apo state, ANP-bound state, BL-bound state, and the both BL-and ANP-bound state. BL binds to the large cavity of two transmembrane domains, inducing a slight conformational change. Additionally, we obtained the structure of ABCB1 in an outward-facing conformation. By comparing these different conformations, we elucidated the possible mechanism of hormone transport by ABCB1. These high-resolution structures help us to understand the structural basis for hormone recognition and transport mechanisms of ABCB1.
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