文献类型： 外文期刊

作者： Pan, Yuan-Fei ¹ ; Zhao, Hailong ⁴ ; Gou, Qin-Yu ¹ ; Shi, Pei-Bo ⁴ ; Tian, Jun-Hua ⁷ ; Feng, Yun ⁸ ; Li, Kun ⁹ ; Yang, Wei-Hong ⁸ ; Wu, De ¹⁰ ; Tang, Guangpeng ¹¹ ; Zhang, Bing ¹² ; Ren, Zirui ⁴ ; Peng, Shiqin ⁴ ; Luo, Geng-Yan ¹ ; Le, Shi-Jia ¹ ; Xin, Gen-Yang ¹ ; Wang, Jing ¹ ; Hou, Xin ¹ ; Peng, Min-Wu ¹ ; Kong, Jian-Bin ¹ ; Chen, Xin-Xin ¹ ; Yang, Chun-Hui ¹ ; Mei, Shi-Qiang ¹ ; Liao, Yu-Qi ¹ ; Cheng, Jing-Xia ¹ ; Wang, Juan ⁸ ; Chaolemen ¹³ ; Wu, Yu-Hui ¹³ ; Wang, Jian-Bo ¹⁴ ; An, Tongqing ¹⁵ ; Huang, Xinyi ¹⁵ ; Eden, John-Sebastian ¹⁶ ; Li, Jun ¹⁸ ; Guo, Deyin ¹ ; Liang, Guodong ²⁰ ; Jin, Xin ⁴ ; Holmes, Edward C. ¹⁷ ; Li, Bo ² ; Wang, Daxi ⁴ ; Li, Junhua ⁴ ; Wu, Wei-Chen ¹ ; Shi, Mang ¹ ;

作者机构： 1.Sun Yat Sen Univ, Sch Med, State Key Lab Biocontrol, Shenzhen Campus, Shenzhen 518107, Peoples R China

2.Fudan Univ, Minist Educ, Sch Life Sci, Key Lab Biodivers Sci & Ecol Engn, Shanghai, Peoples R China

3.Sun Yat Sen Univ, Shenzhen Key Lab Syst Med Inflammatory Dis, Shenzhen Campus, Shenzhen, Peoples R China

4.BGI Res, Shenzhen, Peoples R China

5.BGI Res, Shenzhen Key Lab Unknown Pathogen Identificat, Shenzhen, Peoples R China

6.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China

7.Wuhan Ctr Dis Control & Prevent, Wuhan, Peoples R China

8.Yunnan Inst Endem Dis Control & Prevent, Dept Viral & Rickettsial Dis Control, Yunnan Prov Key Lab Zoonosis Control & Prevent, Dali, Peoples R China

9.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing, Peoples R China

10.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Peoples R China

11.Guizhou Ctr Dis Control & Prevent, Guiyang, Peoples R China

12.Xinjiang Med Univ, Sch Basic Med Sci, Xinjiang Key Lab Mol Biol Endem Dis, Urumqi, Peoples R China

13.Old Barag Banner Ctr Dis Control & Prevent, Hulunbuir, Peoples R China

14.Hulunbuir Ctr Dis Control & Prevent, Hulunbuir, Peoples R China

15.Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Harbin Vet Res Inst, Harbin, Peoples R China

16.Westmead Inst Med Res, Ctr Virus Res, Westmead, NSW, Australia

17.Univ Sydney, Sydney Inst Infect Dis, Sch Med Sci, Sydney, NSW, Australia

18.City Univ Hong Kong, Jockey Club Coll Vet Med & Life Sci, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China

19.Guangzhou Int Bio Isl, Guangzhou Natl Lab, Guangzhou, Peoples R China

20.Chinese Ctr Dis Control & Prevent, Natl Inst viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China

21.Yunnan Univ, Minist Educ, Key Lab Ecosecur Southwest China, Yunnan Key Lab Plant Reprod Adaptat & Evolutionary, Kunming, Peoples R China

22.Yunnan Univ, Inst Biodivers, Ctr Invas Biol, Sch Ecol & Environm Sci, Kunming, Peoples R China

期刊名称：NATURE ECOLOGY & EVOLUTION （ 影响因子：16.8； 五年影响因子：16.9 ）

ISSN： 2397-334X

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a meta-transcriptomic approach, we determined the viromes of 2,438 individual mosquitoes (81 species), spanning similar to 4,000 km along latitudes and longitudes in China. From these data we identified 393 viral species associated with mosquitoes, including 7 (putative) species of arthropod-borne viruses (that is, arboviruses). We identified potential mosquito species and geographic hotspots of viral diversity and arbovirus occurrence, and demonstrated that the composition of individual mosquito viromes was strongly associated with host phylogeny. Our data revealed a large number of viruses shared among mosquito species or genera, enhancing our understanding of the host specificity of insect-associated viruses. We also detected multiple virus species that were widespread throughout the country, perhaps reflecting long-distance mosquito dispersal. Together, these results greatly expand the known mosquito virome, linked viral diversity at the scale of individual insects to that at a country-wide scale, and offered unique insights into the biogeography and diversity of viruses in insect vectors.