Icariin-loaded chitosan/β-glycerophosphate thermosensitive hydrogel enhanced infection control and bone regeneration in canine with infectious bone defects
文献类型： 外文期刊
作者： Shao, Bing 1 ; Fu, Yang 1 ; Li, Bo 1 ; Huo, Siming 1 ; Du, Jiayu 1 ; Zhang, Xuliang 1 ; Yin, Xin 4 ; Li, Yanfei 1 ; Cao, Zheng 1 ; Song, Miao 1 ;
作者机构： 1.Northeast Agr Univ, Coll Vet Med, Dept Heilongjiang Common Anim Dis Prevent & Treatm, Key Lab Prov Educ, 600 Changjiang St, Harbin 150030, Peoples R China
2.Heze Vocat Coll, Dept Vet Med, Heze, Peoples R China
3.Heilongjiang Northeast Agr Univ Anim Hosp Co Ltd, Harbin, Peoples R China
4.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Harbin, Peoples R China
关键词： Icariin; thermosensitive hydrogel; infection control; angiogenesis; bone regeneration
期刊名称：JOURNAL OF BIOMATERIALS APPLICATIONS （ 影响因子：2.5； 五年影响因子：2.7 ）
ISSN： 0885-3282
年卷期： 2025 年 39 卷 7 期
页码：
收录情况： SCI
摘要： Faced with infectious bone defects, the development of a thermosensitive hydrogel containing icariin (ICA) represents a promising therapeutic strategy targeting infection control and bone regeneration. In this study, we prepared and evaluated the physicochemical properties, in vitro and in vivo drug release, antimicrobial activity, anti-inflammatory properties, and bone repair effects of ICA/Chitosan/beta-Glycerophosphate (ICA/CTS/beta-GP) thermosensitive hydrogel. Our findings demonstrate that the ICA/CTS/beta-GP thermosensitive hydrogel undergoes a liquid-to-gel transition at body temperature, which is crucial for maintaining local drug release at the defect site. Additionally, the hydrogel exhibited sustained release of ICA over 28 days, showing high antimicrobial activity against Staphylococcus aureus and good biocompatibility in blood compatibility tests. In a canine model of infectious bone defects, the ICA/CTS/beta-GP thermosensitive hydrogel showed effective infection control and modulated inflammation, vascular formation, and bone factor expression, while also activating the Wnt/beta-catenin signaling pathway. In conclusion, the ICA/CTS/beta-GP thermosensitive hydrogel could control infection and repair bone tissue. Its antimicrobial and osteogenic properties provide hope for its clinical application.
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