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Comprehensive metabolic profiling of dioxin-like compounds exposure in laying hens: Implications for toxicity assessment

文献类型： 外文期刊

作者： Hu, Xiaoxu 1 ; Xu, Tong 1 ; Chen, Yangsheng 1 ; Zhang, Qian 3 ; Tang, Lijuan 4 ; Zheng, Liping 1 ; Wang, Chu 1 ; Wang, Pu 5 ; Dong, Shujun 6 ; Wang, Ruiguo 6 ; Zhang, Su 6 ; Zhang, Qinghua 1 ; Xie, Heidi Qunhui 1 ; Xu, Li 1 ; Zhao, Bin 1 ;

作者机构： 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

3.Beijing Hosp, Natl Ctr Gerontol, Dept Cardiol, Beijing 100730, Peoples R China

4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310024, Peoples R China

5.Jianghan Univ, Sch Environm & Hlth, Hubei Key Lab Ind Pume & Dust Pollut Control, Wuhan 430056, Peoples R China

6.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China

关键词： Polychlorinated dibenzo-p-dioxins; and furans; Dioxin-like polychlorinated; biphenyls; Laying hens; Metabolomic

期刊名称：JOURNAL OF ENVIRONMENTAL SCIENCES （ 影响因子：6.9； 五年影响因子：6.2 ）

ISSN： 1001-0742

年卷期： 2025 年 148 卷

页码：

收录情况： SCI

摘要： The evaluation of toxicity related to polychlorinated dibenzo- p -dioxins and furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) is crucial for a comprehensive risk assessment in real-world exposure scenarios. This study employed a controlled feeding experiment to investigate the metabolic effects of dioxin-like compounds (DLCs) on laying hens via feed exposure. Diets enriched with two concentrations (1.17 and 5.13 pg toxic equivalents (TEQ)/g dry weight (dw)) were administered over 14 days, followed by 28 days of clean feed. Metabolomics analyses of blood samples revealed significant metabolic variations between PCDD/Fs and DL-PCBs exposed groups and controls, reflecting the induced metabolic disruption. Distinct changes were observed in sphingosine, palmitoleic acid, linoleate, linolenic acid, taurocholic acid, indole acrylic acid, and dibutyl phthalate levels, implying possible connections between PCDD/Fs and DL-PCBs toxic effects and energy-neuronal imbalances, along with lipid accumulation and anomalous amino acid metabolism, impacting taurine metabolism. Moreover, we identified three differential endogenous metabolites-L-tryptophan, indole-3-acetaldehyde, and indole acrylic acid-as potential ligands for the aryl hydrocarbon receptor (AhR), suggesting their role in mediating PCDD/Fs and DL -PCBs toxicity. This comprehensive investigation provides novel insights into the metabolic alterations induced by PCDD/Fs and DL -PCBs in laying hens, thereby enhancing our ability to assess risks associated with their exposure in human populations. (c) 2024 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.

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