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Development of a Bioactive Inorganic/organic Composite for Bone Formation Active Drug Carrier

文献类型： 会议论文

第一作者： Sang Ho Ye

作者： Sang Ho Ye 1 ; Masanori Kikuchi;

作者机构： 1.Biomaterials Center, National Institute for Materials Science 1-1,Namiki, Tsukuba,lbaraki 305-0044, Japan

关键词： bone regeneration;β-tricalcium phosphate;poly (L-lactide-co-glycolide-co-ε-caprolactone);mechanical property;biodegradability

会议名称： Bioceramics vol.19 pt.2

主办单位：

页码： 1049,1052-

摘要： To develop a bioactive inorganic/organic composite matrix material, which could be applied in a proactive bone tissue regeneration therapy, a composite of ricalcium phosphate (TCP), and biodegradable poly-(L-lactide-co-glycolide-co-e-caprolactone) (PLGC), was designed and prepared with suitable biodegradable properties and good workability. Several kinds of TCP/PLGC composites with different composition ratio of the TCP and PLGC were prepared homogeneously by a heat-kneading method. The tensile strength of TCP/PLGC composite was changed with increasing of the TCP composition. And the maximum tensile strength and Young's modulus of TCP(75)/PLGC (the mass ratio of TCP and PLGC=75:25) was increased significantly in comparison with that of the others composites and pure PLGC sample sheet. In a soaking test with a phosphate-buffered saline, the mechanical strength of TCP/PLGC composites was gradually decreased with decreasing of the molecular weight of PLGC in the composites within one month. There is no difference in the tensile strength between the TCP/PLGC composite and the pure PLGC sample after one month soaking test. We are expecting that the TCP/PLGC composite with good bioactive property, suitable biodegradable properties and good workability could be applied in a proactive bone tissue regeneration therapy to realize simple, effective, and safe orthopedic substitutes and healing therapies.

分类号： [ "R318.08" , "R318.08"]

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