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Assessment of QT Interval Dynamics Induced by Heart Rate Changes Through Bivariate Phase-Rectified Signal Averaging

文献类型: 会议论文

第一作者: Alba Martín-Yebra

作者: Alba Martín-Yebra 1 ; Joaquín Molinos 2 ; Juan Pablo Martínez 3 ;

作者机构: 1.BSICoS Group, Aragón Institute of Engineering Research, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain|CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain|BSICOS Group University of Zaragoza, Zaragoza, Spain

2.BSICoS Group, Aragón Institute of Engineering Research, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain

3.BSICoS Group, Aragón Institute of Engineering Research, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain|CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain

关键词: Heart rate;Sociology;Phase frequency detectors;Biomarkers;Hazards;Recording;Cardiovascular diseases

会议名称: Computing in Cardiology Conference

主办单位:

页码: 1-4

摘要: The aim of this study is to investigate the relationship between the RR and QT series through the bivariate phase-rectified signal averaging (BPRSA) computed during RR decelerations, assuming that recurrent changes in the of RR (trigger signal) cause recurrent responses in QT (target signal). Moreover, the prognostic value of new deceleration-related indices in a chronic heart failure (CHF) population are assessed. The 24-hour QT and RR series were extracted from 651 Holter recordings acquired from CHF patients. First, deceleration anchor points were identified as RR increases in the trigger signal, and segments of $2L+1$ samples around them were extracted from both the trigger and the target. Finally, all segments are aligned with respect to the anchors and averaged. The deceleration capacity (DC) and new bivariate deceleration-based biomarkers were computed from the average PRSA and BPRSA signals, respectively. Patients suffering from pump failure death (PFD) had significant lower DC and $QT$ increase after heart rate deceleration. Moreover, the proposed BPRSA indices were associated to PFD in the studied population, with hazard ratios of 2.6 and 2.2 obtained for $Delta_{1,0}^{BPRSA}$ and $Delta_{0,-1}^{BPRSA}$ indices, respectively. In conclusion, a large $QT$ increase in the beats immediately after heart rate deceleration is an indicator of higher mortality risk in the studied population.

分类号: tp3

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