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Characterization of Cardiopulmonary Coupling in Pediatric Patients with Obstructive Sleep Apnea

文献类型： 会议论文

第一作者： Pablo Arma?ac-Julián

作者： Pablo Arma?ac-Julián 1 ; Adrián Martín-Montero 2 ; Salla Hietakoste 3 ; Jesús Lázaro 1 ; Samu Kainulainen 3 ; David Gozal 4 ; Roberto Hornero 2 ; Pablo Laguna 1 ; Gonzalo Gutiérrez-Tobal 2 ; Eduardo Gil 1 ; Raquel Bailón 1 ;

作者机构： 1.CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain|BSICoS group, Instituto de Investigacion en Ingeniería de Aragón, Zaragoza, Spain

2.CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain|GIB Group, University of Valladolid, Valladolid, Spain

3.Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

4.Department of Child Health, Child Health Research Institute, University of Missouri, School of Medicine, Columbia, MO, United States

关键词： Couplings;Pathology;Time-frequency analysis;Pediatrics;Hafnium;Coherence;Sleep apnea

会议名称： Computing in Cardiology Conference

主办单位：

页码： 1-4

摘要： This study aims to investigate the use of cardiopulmonary coupling (CPC), as biomarker for characterizing obstructive sleep apnea (OSA) severity in children. CPC analysis is based on the time-frequency coherence (TFC) between the respiratory effort signal and heart rate variability. We analyzed 255 children with no, mild, moderate, and severe OSA during wake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep. Results showed that the TFC in the low-frequency (LF) band increased significantly with the severity of OSA in both NREM (p<0.001) and REM sleep (p<0.001). Conversely, the TFC in the HF band, the parameter estimating CPC, is significantly lower for increasing OSA severity categories during NREM (p=0.02) and REM (p=0.03). The findings suggest that TFC could be a useful biomarker for assessing OSA severity in children, and could provide additional information about underlying pathological mechanisms.

分类号： tp3

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