文献类型： 外文期刊
作者： Ding, Ziqiang 1 ; Wang, Xingdong 1 ; Guo, Shaoke 1 ; Kang, Yandong 1 ; Cao, Mengli 1 ; Hu, Liyan 1 ; Zhang, Ben 1 ; Xiong, Lin 1 ; Pei, Jie 1 ; Yang, Tao 3 ; Guo, Xian 1 ;
作者机构： 1.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Key Lab Yak Breeding Gansu Prov, Lanzhou 730050, Peoples R China
2.Minist Agr & Rural Affairs, Key Lab Anim Genet & Breeding Tibetan Plateau, Lanzhou 730050, Peoples R China
3.Haibei Anim Husb Sci & Technol Demonstrat Pk Manag, Haibei 810299, Peoples R China
关键词：
Epididymis; Reproductive physiology;
期刊名称：BMC GENOMICS （ 影响因子：3.7； 五年影响因子：4.2 ）
ISSN： 1471-2164
年卷期： 2025 年 26 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundThe epididymis is essential for sperm maturation. During sperm maturation, markable alterations of the payload of small noncoding RNAs are observed in the epididymis, which indicated the role of epigenetic alterations in sperm maturation. However, the N6-Methyladenosine (m6A) modification profile of the epididymis remains unelucidated. Therefore, in this study, we assessed the m6A modification levels in the caput, corpus, and cauda of the yak epididymis using a combination of methylated RNA immunoprecipitation and RNA sequencing.ResultsThe m6A levels were significantly increased in the corpus of the epididymis. Functional enrichment analysis of differentially methylated RNA (DMR) between the corpus and caput group revealed the significant enrichment of DMRs in the gap junction, ErbB signaling pathway, and mTOR signaling pathway, which participate in cell communication and sperm maturation. In addition, the DMRs of cauda-vs-corpus group were enriched in apoptosis, the FoxO signaling pathway, the PI3K-Akt signaling pathway, and the tumor necrosis factor signaling pathway that were associated with sperm autophagy, oxidative stress, and sperm maturation. Furthermore, we identified the key genes exhibiting significant changes in m6A levels but with no differences in RNA levels, including YY1-associated factor 2, forkhead box J2, and forkhead box O1. This finding indicated that m6A modifications affect these genes during translation, thereby participating in sperm maturation.ConclusionsIn summary, we generated the m6A profile of the yak epididymis, which will aid in further elucidating the maturation process of sperm and reveal more information related to male infertility.
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