文献类型： 外文期刊

作者： Feng, Zhiming ¹ ; Gao, Peng ¹ ; Wang, Guangda ¹ ; Kang, Houxiang ⁴ ; Zhao, Jianhua ¹ ; Xie, Wenya ¹ ; Chen, Rujia ¹ ; Ju, Ran ¹ ; Wang, Xuli ⁴ ; Wei, Zhaogen ¹ ; Zhang, Huimin ¹ ; Zhang, Jinqiao ¹ ; Zhang, Yafang ¹ ; Hu, Keming ¹ ; Sun, Quanyi ¹ ; Zhu, Yuntao ¹ ; Xiong, Yehui ⁵ ; Liu, Xi ⁶ ; Chen, Xijun ² ; Chen, Zongxiang ¹ ; Yang, Chao ⁷ ; Liu, Jun ⁷ ; Wang, Guo-Liang ⁹ ; Zhang, Sheng-Wei ¹⁰ ; Yang, Zefeng ¹ ; Zuo, Shimin ¹ ;

作者机构： 1.Yangzhou Univ, Jiangsu Key Lab Crop Genom & Mol Breeding, Zhongshan Biol Breeding Lab, Key Lab Plant Funct Genom,Minist Educ,Agr Coll, Yangzhou, Peoples R China

2.Yangzhou Univ, Jiangsu Coinnovat Ctr Modern Prod Technol Grain Cr, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou, Peoples R China

3.Jiangsu Prov, Lixiahe Agr Res Inst, Yangzhou, Peoples R China

4.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing, Peoples R China

5.Chinese Acad Agr Sci, Inst Crop Sci, State Key Lab Crop Gene Resources & Breeding, Beijing, Peoples R China

6.Huaiyin Normal Univ, Jiangsu Key Lab Ecoagr Biotechnol Hongze Lake, Huaian, Jiangsu, Peoples R China

7.China Agr Univ, State Key Lab Agrobiotechnol, Beijing, Peoples R China

8.China Agr Univ, MOA Key Lab Monitoring & Green Management Crop Pes, Beijing, Peoples R China

9.Ohio State Univ, Dept Plant Pathol, Columbus, OH USA

10.Hebei Normal Univ, Coll Life Sci,Hebei Key Lab Mol & Cellular Biol, Hebei Collaborat Innovat Ctr Cell Signaling & Envi, Minist Educ,Key Lab Mol & Cellular Biol, Shijiazhuang, Peoples R China

11.Yangzhou Univ, Inst Agr Sci & Technol Dev, Joint Int Res Lab Agr & Agriprod Safety, Minist Educ China, Yangzhou, Peoples R China

期刊名称：NATURE GENETICS （ 影响因子：29.0； 五年影响因子：37.4 ）

ISSN： 1061-4036

年卷期： 2025 年 57 卷 8 期

页码：

收录情况： SCI

摘要： Sheath blight (ShB), caused by necrotrophic fungus Rhizoctonia solani, is one of the most serious rice diseases worldwide. To the best of our knowledge, no genes with high potential for rice ShB resistance breeding have been previously characterized. Here we identify a ShB resistance receptor-like kinase 1 (SBRR1) gene via a genome-wide association study. The SBRR1-R elite allele, containing a 256-bp insertion in its promoter, is preferentially present in indica varieties in geographical regions with highly favorable conditions for ShB development. Introduction of SBRR1-R into a commercial japonica rice variety significantly reduces yield loss under severe ShB disease pressure. Transcription factor bHLH57 specifically binds to the 256-bp sequence and accounts for highly induced expression and stronger resistance of SBRR1-R. Localization of SBRR1 on plasma membrane, aided by SBRR1-interaction-protein 1, and phosphorylation of SBRR1 are required for SBRR1 to rapidly upregulate downstream chitinase genes for resistance. These findings offer mechanistical insights into ShB resistance hidden in natural rice varieties.