Ubiquitination of OsCSN5 by OsPUB45 activates immunity by modulating the OsCUL3a-OsNPR1 module
文献类型： 外文期刊
作者： Zhang, Chongyang 1 ; Fang, Liang 1 ; He, Feng 1 ; You, Xiaoman 1 ; Wang, Min 1 ; Zhao, Tianxiao 1 ; Hou, Yanyan 1 ; Xiao, Ning 4 ; Li, Aihong 4 ; Yang, Jian 5 ; Ruan, Jue 2 ; Francis, Frederic 3 ; Wang, Guo-Liang 6 ; Wang, Ruyi 1 ; Ning, Yuese 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 440307, Peoples R China
3.Univ Liege, Funct & Evolutionary Entomol, Gembloux Agrobio Tech, Gembloux, Belgium
4.Inst Agr Sci Lixiahe Reg Jiangsu, Yangzhou 225009, Peoples R China
5.Ningbo Univ, Inst Plant Virol, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Biotechnol Plant Protect,Minist Agr & Rur, Ningbo 315211, Peoples R China
6.Ohio State Univ, Dept Plant Pathol, Columbus, OH 43210 USA
期刊名称：SCIENCE ADVANCES （ 影响因子：12.5； 五年影响因子：14.1 ）
ISSN： 2375-2548
年卷期： 2025 年 11 卷 1 期
页码：
收录情况： SCI
摘要： The COP9 signalosome (CSN) is a highly conserved protein complex in eukaryotes, with CSN5 serving as its critical catalytic subunit. However, the role of CSN5 in plant immunity is largely unexplored. Here, we found that suppression of OsCSN5 in rice enhances resistance against the fungal pathogen Magnaporthe oryzae and the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo) without affecting growth. OsCSN5 is ubiquitinated and degraded by the E3 ligase OsPUB45. Overexpression of OsPUB45 increased resistance against M. oryzae and Xoo, while dysfunction of OsPUB45 decreased resistance. In addition, OsCSN5 stabilized OsCUL3a to promote the degradation of a positive regulator OsNPR1. Overexpression of OsPUB45 compromised accumulation of OsCUL3a, leading to stabilization of OsNPR1, whereas mutations in OsPUB45 destabilized OsNPR1. These findings suggest that OsCSN5 stabilizes OsCUL3a to facilitate the degradation of OsNPR1, preventing its constitutive activation without infection. Conversely, OsPUB45 promotes the degradation of OsCSN5, contributing to immunity activation upon pathogen infection.
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