Degradation of AtSRC2 by SKP1/BTB/POZ domain effectors in Heterodera schachtii inhibits RBOHF via ROS and enhances infection
文献类型： 外文期刊
作者： Yao, Ke 1 ; Zhang, Xin 3 ; Jian, Jinzhuo 1 ; Ning, Yuese 1 ; Zhang, Chunhui 4 ; Zheng, Jingwu 5 ; Wu, Duqing 6 ; Kong, Lingan 1 ; Huang, Wenkun 1 ; Liu, Shiming 1 ; Peng, Deliang 1 ; Peng, Huan 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China
2.Dezhou Univ, Inst Biophys, Shandong Key Lab Biophys, Dezhou 253023, Peoples R China
3.Henan Univ, Coll Life Sci, State Key Lab Crop Stress Adaptat & Improvement, Kaifeng 475001, Henan, Peoples R China
4.Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China
5.Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou 310030, Zhejiang, Peoples R China
6.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
关键词：
effector;
期刊名称：NEW PHYTOLOGIST （ 影响因子：8.1； 五年影响因子：10.3 ）
ISSN： 0028-646X
年卷期： 2025 年 247 卷 4 期
页码：
收录情况： SCI
摘要： Upon pathogen infection, plants trigger a reactive oxygen species (ROS) burst to activate immunity. Although some effectors secreted by plant-parasitic nematodes are known to suppress ROS-mediated immunity, there are limited studies examining the regulation of respiratory burst oxidase homologs (RBOH)-dependent ROS pathways by these nematodes. Using developmental expression analysis, in situ hybridization, and immunohistochemical tests, we found that both Hs28B03 and Hs8H07 were expressed and secreted during the early parasitism by Heterodera schachii. Transgenic Arabidopsis plants were used to assess the role of Hs28B03 and Hs8H07 in H. schachii parasitism. Yeast two-hybrid was used to identify host targets in Arabidopsis. We identified Hs28B03 and Hs8H07 from H. schachtii, which play a crucial role in promoting nematode infection and parasitism, as well as inhibiting host immune responses. Hs28B03 and Hs8H07 harbor the SKP1/BTB/POZ domain and exhibit the capacity to mimic the host's SKP1 proteins, allowing them to regulate the ubiquitin pathway within the plant. Hs28B03 and Hs8H07 specifically target and degrade the host's AtSRC2 protein, inhibiting the Ca2+-dependent production of ROS mediated by RBOHF, enhancing Arabidopsis susceptibility to H. schachtii. In conclusion, nematodes can secrete effectors that mimic plant ubiquitination pathway components, suppressing ROS bursts via the RBOHF pathway, thereby facilitating parasitism.
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