您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

The design and engineering of synthetic genomes

文献类型： 外文期刊

作者： James, Joshua S. 1 ; Dai, Junbiao 3 ; Chew, Wei Leong 2 ; Cai, Yizhi 1 ;

作者机构： 1.Univ Manchester, Manchester Inst Biotechnol, Manchester, England

2.ASTAR, Genome Inst Singapore GIS, Singapore, Singapore

3.Chinese Acad Agr Sci, Minist Agr & Rural Affairs,Agr Genom Inst Shenzhen, Shenzhen Branch,Genome Anal Lab, Guangdong Lab Lingnan Modern Agr,Shenzhen Key Lab, Shenzhen, Peoples R China

4.Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen Key Lab Synthet Genom,Guangdong Prov Key, Shenzhen, Peoples R China

期刊名称：NATURE REVIEWS GENETICS （ 影响因子：52.0； 五年影响因子：57.1 ）

ISSN： 1471-0056

年卷期： 2025 年 26 卷 5 期

页码：

收录情况： SCI

摘要： Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect fundamental questions of genome function and to engineer organisms for diverse applications, including bioproduction of high-value chemicals and biologics, advanced cell therapies, and stress-tolerant crops. Recent progress has been fuelled by advancements in DNA synthesis, assembly, delivery and editing. Computational innovations, such as the use of artificial intelligence to provide prediction of function, also provide increasing capabilities to guide synthetic genome design and construction. However, translating synthetic genome-scale projects from idea to implementation remains highly complex. Here, we aim to streamline this implementation process by comprehensively reviewing the strategies for design, construction, delivery, debugging and tailoring of synthetic genomes as well as their potential applications. In this Review, James et al. provide an overview of approaches for planning, constructing, and fine-tuning synthetic genomes and describe their potential applications.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台