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Towards next-generation DNA encryption via an expanded genetic system

文献类型： 外文期刊

作者： Huang, Xiaoluo 2 ; Hou, Zhaohua 1 ; Qiang, Wei 2 ; Wang, Honglei 3 ; Wang, Xiangxiang 1 ; Chen, Xiaoxu 1 ; Hu, Xin 1 ; Dai, Junbiao 2 ; Li, Lingjun 3 ; Zhao, Guanghou 1 ;

作者机构： 1.Northwestern Polytech Univ, Sch Ecol & Environm, Xian 710129, Peoples R China

2.Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen Key Lab Synthet Genom,Guangdong Prov Key, Shenzhen 518055, Peoples R China

3.Henan Normal Univ, Sch Chem & Chem Engn,Key Lab Green Chem Med & Reac, Collaborat Innovat Ctr Henan Prov Green Mfg Fine C, Henan Key Lab Organ Funct Mol & Drug Innovat,Minis, Xinxiang 453007, Peoples R China

4.Henan Normal Univ, State Key Lab Antiviral Drug, Xinxiang 453007, Peoples R China

5.Henan Normal Univ, Pingyuan Lab, Xinxiang 453007, Peoples R China

6.Chinese Acad Agr Sci, Agr Genom Inst, Shenzhen Branch,Minist Agr & Rural Affairs, Guangdong Lab Lingnan Modern Agr,Genome Anal Lab, Shenzhen 518000, Peoples R China

关键词： multilevel DNA encryption; unnatural base pair; Codec algorithm; DNA data storage

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：17.1； 五年影响因子：17.7 ）

ISSN： 2095-5138

年卷期： 2025 年 12 卷 4 期

页码：

收录情况： SCI

摘要： Information encryption based on DNA data archiving, referred to as DNA encryption, has been advocated for decades and has become highly appealing owing to its remarkable advantages, e.g. high storage capacity, complexity and programmability. Early DNA encryption schemes primarily leveraged the natural four-letter genetic alphabet for data storage, with message-storing DNA sequences easily decrypted by routine DNA sequencing, which is consequently vulnerable to attack and faces severe security challenges. Here, an unnatural base pair (UBP), dNaM-dTPT3, was introduced into the message and/or index DNA sequences, which can be stored either in vitro or in vivo; this approach achieved the bioorthogonal encryption of 'secret' messages, where message DNAs could be selectively, faithfully and readily retrieved or read exclusively in the presence of unnatural bases. Furthermore, a separative computational algorithm, named IM-Codec, was developed to encrypt the data into a 'key sequence' and an 'information sequence' through UBP insertion. Finally, a UBP-based multilevel DNA encryption approach was developed and validated for data encryption and decryption. The employment of the UBP expanded genetic system for data encryption should provide valuable solutions for archiving highly confidential data and thus usher in a new era of DNA encryption.

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