文献类型： 外文期刊

作者： Zhao, Jin ¹ ; Wan, Wenbo ¹ ; Yu, Kang ¹ ; Lemey, Philippe ³ ; Pettersson, John H. -O. ⁴ ; Bi, Yuhai ⁷ ; Lu, Meng ¹ ; Li, Xinxin ⁸ ; Chen, Zhuohang ¹ ; Zheng, Mengdi ⁸ ; Yan, Ge ² ; Dai, Jianjun ² ; Li, Yuxing ¹ ; Haerheng, Ayidana ¹ ; He, Na ¹ ; Tu, Changchun ⁹ ; Suchard, Marc A. ¹⁰ ; Holmes, Edward C. ¹³ ; He, Wan-Ting ² ; Su, Shuo ¹ ;

作者机构： 1.Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Sch Publ Hlth, Dept Epidemiol, Shanghai, Peoples R China

2.China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med, Nanjing, Peoples R China

3.Katholieke Univ Leuven, Rega Inst, Dept Microbiol Immunol & Transplantat, Lab Clin & Epidemiol Virol, Leuven, Belgium

4.Uppsala Univ, Dept Med Sci, Clin Microbiol, Uppsala, Sweden

5.Uppsala Univ Hosp, Clin Microbiol & Hosp Hyg, Uppsala, Sweden

6.Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia

7.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

8.Nanjing Agr Univ, Acad Adv Interdisciplinary Studies, Coll Vet Med, Inst Immunol,Jiangsu Engn Lab Anim Immunol, Nanjing, Peoples R China

9.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China

10.Univ Calif Los Angeles, David Geffen Sch Med, Fielding Sch Publ Hlth, Dept Human Genet & Biomath, Los Angeles, CA 90095 USA

11.Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA USA

12.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA USA

13.Univ Sydney, Sch Med Sci, Sydney, NSW, Australia

14.Lab Data Discovery Hlth Ltd, Hong Kong, Peoples R China

期刊名称：NATURE （ 影响因子：48.5； 五年影响因子：55.0 ）

ISSN： 0028-0836

年卷期： 2024 年 634 卷 8035 期

页码：

收录情况： SCI

摘要： Animals such as raccoon dogs, mink and muskrats are farmed for fur and are sometimes used as food or medicinal products1,2, yet they are also potential reservoirs of emerging pathogens3. Here we performed single-sample metatranscriptomic sequencing of internal tissues from 461 individual fur animals that were found dead due to disease. We characterized 125 virus species, including 36 that were novel and 39 at potentially high risk of cross-species transmission, including zoonotic spillover. Notably, we identified seven species of coronaviruses, expanding their known host range, and documented the cross-species transmission of a novel canine respiratory coronavirus to raccoon dogs and of bat HKU5-like coronaviruses to mink, present at a high abundance in lung tissues. Three subtypes of influenza A virus-H1N2, H5N6 and H6N2-were detected in the lungs of guinea pig, mink and muskrat, respectively. Multiple known zoonotic viruses, such as Japanese encephalitis virus and mammalian orthoreovirus4,5, were detected in guinea pigs. Raccoon dogs and mink carried the highest number of potentially high-risk viruses, while viruses from the Coronaviridae, Paramyxoviridae and Sedoreoviridae families commonly infected multiple hosts. These data also reveal potential virus transmission between farmed animals and wild animals, and from humans to farmed animals, indicating that fur farming represents an important transmission hub for viral zoonoses. Fur farming represents an important hub of cross-species transmission for viral zoonoses.