Stomach as the target organ of Rickettsia heilongjiangensis infection in C57BL/6 mice identified by click chemistry
文献类型： 外文期刊
作者： Wang, Juan 1 ; Du, Li-Feng 3 ; Zhang, Ming-Zhu 3 ; Wei, Wei 2 ; Chen, Zi-Yun 2 ; Zhang, Xu 5 ; Xiong, Tao 2 ; Wang, Zhen-Fei 6 ; Xia, Luo-Yuan 2 ; Jiang, Jia-Fu 2 ; Li, Wen-Jun 5 ; Zhu, Dai-Yun 2 ; Jia, Na 2 ; Cao, Wu-Chun 2 ;
作者机构： 1.Gannan Med Univ, Sch Publ Hlth & Hlth Management, Ganzhou 341000, Jiangxi, Peoples R China
2.Acad Mil Med Sci, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
3.Shandong Univ, Inst EcoHlth, Sch Publ Hlth, 44 Wenhuaxi St, Jinan 250012, Shandong, Peoples R China
4.Fujian Med Univ, Sch Publ Hlth, Fuzhou 350122, Fujian, Peoples R China
5.Chinese Acad Sci, Guangdong Key Lab Nanomed CAS HK Joint Lab Biomat, Shenzhen Engn Lab Nanomed & Nanoformulat, Shenzhen Inst Adv Technol SIAT, Shenzhen 518055, Peoples R China
6.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China
期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：5.2； 五年影响因子：5.6 ）
ISSN：
年卷期： 2024 年 7 卷 1 期
页码：
收录情况： SCI
摘要： Spotted fever group rickettsiae (SFGR) are obligate intracellular bacteria that cause spotted fever. The limitations of gene manipulation pose great challenges to studying the infection mechanisms of Rickettsia. By combining bioorthogonal metabolism and click chemistry, we developed a method to label R. heilongjiangensis via azide moieties and achieved rapid pathogen localization without complex procedures. Moreover, we constructed a C57BL/6 mice infection model by simulating tick bites and discovered that the stomach is the target organ of R. heilongjiangensis infection through in vivo imaging systems, which explained the occurrence of gastrointestinal symptoms following R. heilongjiangensis infection in some cases. This study offers a unique perspective for subsequent investigations into the pathogenic mechanisms of SFGR and identifies a potential target organ for R. heilongjiangensis.
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