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A simple approach to fabricate chitosan-delivered avermectin controlled release microparticles for improved efficacy and reduced residues

文献类型： 外文期刊

作者： Kong, Xiang-Ping 1 ; Li, Wei-Kun 1 ; Liu, Jun-Hao 2 ; Zhao, Pengyue 3 ; Ge, Jia-Cheng 4 ; Jiang, Shoulin 1 ; Li, Weina 1 ; Luo, Lan 2 ; Wang, Juan 1 ;

作者机构： 1.Qingdao Agr Univ, Coll Chem & Pharm, Qingdao 266109, Shandong, Peoples R China

2.Qingdao Agr Univ, Coll Plant Hlth & Med, Qingdao 266109, Shandong, Peoples R China

3.Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing 100193, Peoples R China

4.Hailir Pesticides & Chem Grp Co Ltd, Qingdao 266109, Shandong, Peoples R China

关键词： Chitosan; Avermectin; Synergistic effect

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 301 卷

页码：

收录情况： SCI

摘要： The presence of a synergistic effect between carrier and insecticide in controlled release formulations is highly desirable to improve efficacy to target pests and reduce insecticide use. Herein, controlled release microparticles of avermectin (AVM) were fabricated using natural chitosan (CTS) as a carrier by a pH adjustment method. The resulted AVM@CTS microparticles displayed high encapsulation efficiency (73.3 %), outstanding photostability, obvious pH/temperature sensitivity, and good deposition behavior on Chinese cabbage leaves. Instrument detections in combination with molecular dynamics simulations showed that AVM interacted with CTS mainly through physical adsorption, adhesion, and weak H-bonds. In vitro release data of the controlled release formulation obeyed the first-order kinetic equation. Toxicity tests exhibited a significantly synergistic effect between CTS and AVM, resulting in better quick-acting and long-term efficacy against Plutella xylostella larvae than that of the AVM acetone solution. The 72 h LC50 of the formulation for a 21-day efficacy was 12.73 mg/L, much lower than the value (31.53 mg/L) of the AVM solution. Moreover, the AVM@CTS microparticles exhibited shorter half-life (19.6 days) than the unformulated AVM (23.0 days) under natural conditions in soil. This work contributes to the development of controlled release system with carrier-insecticide synergistic effect for sustainable pest control.

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