文献类型： 外文期刊

作者： Lyu, Yang ¹ ; Wang, Fuwen ¹ ; Cheng, Haijian ¹ ; Han, Jing ⁴ ; Dang, Ruihua ¹ ; Xia, Xiaoting ¹ ; Wang, Hui ⁵ ; Zhong, Jincheng ⁵ ; Lenstra, Johannes A. ⁶ ; Zhang, Hucai ⁷ ; Han, Jianlin ⁹ ; Machugh, David E. ¹¹ ; Medugorac, Ivica ¹³ ; Upadhyay, Maulik ¹³ ; Leonard, Alexander S. ¹⁴ ; Ding, He ² ; Yang, Xiaorui ² ; Wang, Ming-Shan ¹⁵ ; Quji, Suolang ¹⁶ ; Zhuzha, Basang ¹⁶ ; Quzhen, Pubu ¹⁷ ; Wangmu, Silang ¹⁶ ; Cangjue, Nima ¹⁶ ; Wa, Da ¹⁶ ; Ma, Weidong ¹⁸ ; Liu, Jianyong ¹⁹ ; Zhang, Jicai ¹⁹ ; Huang, Bizhi ¹⁹ ; Qi, Xingshan ²⁰ ; Li, Fuqiang ²¹ ; Huang, Yongzhen ¹ ; Ma, Yun ²² ; Wang, Yu ¹ ; Gao, Yuanpeng ⁴ ; Lu, Wenfa ² ; Lei, Chuzhao ¹ ; Chen, Ningbo ¹ ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China

2.Jilin Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Prod, Prod Qual, Changchun 130118, Peoples R China

3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan 250000, Peoples R China

4.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Peoples R China

5.Southwest Minzu Univ, Key Lab Qinghai Tibetan Plateau Anim Genet Resourc, Sichuan Prov & Minist Educ, Chengdu 610000, Peoples R China

6.Univ Utrecht, Fac Vet Med, NL-3584 CM Utrecht, Netherlands

7.Yunnan Univ, Inst Ecol Res & Pollut Control Plateau Lakes, Sch Ecol & Environm Sci, Kunming 650500, Peoples R China

8.Southwest United Grad Sch, Kunming 650500, Peoples R China

9.Yazhouwan Natl Lab, Sanya 572024, Peoples R China

10.Chinese Acad Agr Sci CAAS, Inst Anim Sci, CAAS ILRI Joint Lab Livestock & Forage Genet Resou, Beijing, Peoples R China

11.Univ Coll Dublin, UCD Sch Agr & Food Sci, Anim Genom Lab, Dublin D04V1W8, Ireland

12.Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin D04 V1W8, Ireland

13.Ludwig Maximilians Univ Munchen, Dept Vet Sci, Populat Genom Grp, D-82152 Martinsried, Germany

14.Swiss Fed Inst Technol, Anim Genom, Univ Str 2, CH-8006 Zurich, Switzerland

15.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Yunnan Lab Mol Biol Domest Anim, Kunming 650223, Peoples R China

16.Inst Anim Husb & Vet Sci, Xizang Autonomous Reg Acad Agr & Anim Husb Sci, Lhasa 850000, Peoples R China

17.Shigatse City Kangma Cty Shaogang Township Agr & A, Dept Gastr Canc Surg, Shigatse 200032, Peoples R China

18.Shaanxi Prov Agr & Husb Breeding Farm, Fufeng 722203, Peoples R China

19.Yunnan Acad Grassland & Anim Sci, Kunming 650212, Peoples R China

20.Anim Husb Bur Biyang Cty, Biyang 463700, Peoples R China

21.Hunan Tianhua Ind Corp Ltd, Lianyuan, Peoples R China

22.Ningxia Univ, Ningxia Hui Autonomous Reg, Key Lab Ruminant Mol & Cellular Breeding, Sch Agr, Yinchuan 750021, Ningxia, Peoples R China

关键词： Tibetan cattle; Introgression; High-altitude adaptation; Noncoding variant; Cis-regulation

期刊名称：SCIENCE BULLETIN （ 影响因子：21.1； 五年影响因子：17.6 ）

ISSN： 2095-9273

年卷期： 2024 年 69 卷 21 期

页码：

收录情况： SCI

摘要： During the past 3000 years, cattle on the Qinghai-Xizang Plateau have developed adaptive phenotypes under the selective pressure of hypoxia, ultraviolet (UV) radiation, and extreme cold. The genetic mechanism underlying this rapid adaptation is not yet well understood. Here, we present whole-genome resequencing data for 258 cattle from 32 cattle breeds/populations, including 89 Tibetan cattle representing eight populations distributed at altitudes ranging from 3400 m to 4300 m. Our genomic analysis revealed that Tibetan cattle exhibited a continuous phylogeographic cline from the East Asian taurine to the South Asian indicine ancestries. We found that recently selected genes in Tibetan cattle were related to body size (HMGA2 and NCAPG) and energy expenditure (DUOXA2). We identified signals of sympatric introgression from yak into Tibetan cattle at different altitudes, covering 0.64%-3.26% of their genomes, which included introgressed genes responsible for hypoxia response (EGLN1), cold adaptation (LRP11), DNA damage repair (LATS1), and UV radiation resistance (GNPAT). We observed that introgressed yak alleles were associated with noncoding variants, including those in present EGLN1. In Tibetan cattle, three yak introgressed SNPs in the EGLN1 promoter region reduced the expression of EGLN1, suggesting that these genomic variants enhance hypoxia tolerance. Taken together, our results indicated complex adaptation processes in Tibetan cattle, where recently selected genes and introgressed yak alleles jointly facilitated rapid adaptation to high-altitude environments. (c) 2024 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.