Epidemiological characteristics of infectious bursal disease virus (IBDV) in China from 2023 to 2024: Mutated very virulent IBDV (mvvIBDV) is associated with atypical IBD
文献类型： 外文期刊
作者： Yu, Hangbo 1 ; Wang, Guodong 1 ; Zhang, Wenying 1 ; Wu, Ziwen 1 ; Niu, Xinxin 1 ; Huang, Mengmeng 1 ; Zhang, Yulong 1 ; Liu, Runhang 1 ; Han, Jinze 1 ; Xu, Mengmeng 1 ; Han, Jingzhe 1 ; Ling, Dan 1 ; Ke, Erjing 1 ; Wang, Suyan 1 ; Cui, Hongyu 1 ; Zhang, Yanping 1 ; Chen, Yuntong 1 ; Liu, Yongzhen 1 ; Duan, Yulu 1 ; Gao, Yulong 1 ; Qi, Xiaole 1 ;
作者机构： 1.Chinese Acad Agr Sci, Harbin Vet Res Inst, Avian Immunosuppress Dis Div, State Key Lab Anim Dis Control & Prevent, 678 Haping Rd, Harbin 150069, Heilongjiang Pr, Peoples R China
2.Chinese Acad Agr Sci, Harbin Vet Res Inst, WOAH Reference Lab Infect Bursal Dis, Harbin 150069, Peoples R China
3.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China
关键词： Atypical IBD; Novel variant IBDV (nVarIBDV); Mutated very virulent IBDV (mvvIBDV); Pathogenicity; Subclinical symptoms
期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）
ISSN： 0032-5791
年卷期： 2025 年 104 卷 7 期
页码：
收录情况： SCI
摘要： Infectious bursal disease (IBD), caused by the infectious bursal disease virus (IBDV), threatens the global poultry industry with acute immunosuppression. The non-lethal novel variant IBDV (nVarIBDV) has been identified as the primary cause of a new outbreak of atypical IBD in China. However, since 2023, several poultry farms in China have continuously reported the detection of vvIBDV in chicken flocks exhibiting atypical IBD characteristics. To analyze this abnormal problem, the prevalence of IBDV in major poultry farming areas in China from 2023 to 2024 was monitored. Our epidemiological survey revealed four coexisting IBDV strains in China, nVarIBDV (69.9 %, 65/93) ranked the first, followed by vvIBDV (16.1 %, 15/93), attIBDV (8.6 %, 8/93), and cIBDV (5.4 %, 5/93). Notably, all these 15 vvIBDV strains detected in this study harbored single or combination mutations in the VP2 hypervariable region (HVR) including residue 279: D279N (seven strains), G254D/I256L/ D279N (one strain), or A222T/G254D/I256L/D279N (seven strains). Furthermore, one representative strain of IBDV-NMG23-1701 which contained the D279N mutation was isolated. In the phylogenetic tree constructed based on the IBDV genome, IBDV-NMG23-1701 was located in the vvIBDV branch. However, IBDV-NMG23-1701 did not kill chickens directly but induced severe subclinical symptoms of atypical IBD. We named these strains mutated vvIBDV (mvvIBDV), which genotypically belonged to vvIBDV but exhibited atypical IBD symptoms. The mvvIBDV has been detected in several major poultry farming areas in China. This is the first study to identify mvvIBDV as a new pathogen causing atypical IBD, providing a scientific basis for optimizing prevention and control strategies.
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