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"Cell Disk" DNA Storage System Capable of Random Reading and Rewriting

文献类型： 外文期刊

作者： Hou, Zhaohua 1 ; Qiang, Wei 2 ; Wang, Xiangxiang 1 ; Chen, Xiaoxu 1 ; Hu, Xin 1 ; Han, Xuye 1 ; Shen, Wenlu 1 ; Zhang, Bing 1 ; Xing, Peng 1 ; Shi, Wenping 1 ; Dai, Junbiao 2 ; Huang, Xiaoluo 2 ; Zhao, Guanghou 1 ;

作者机构： 1.Northwestern Polytech Univ, Sch Ecol & Environm, 1 Dongxiang Rd, Xian 710129, Shaanxi, Peoples R China

2.Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen Key Lab Synthet Genom,Guangdong Prov Key, Shenzhen 518055, Guangdong, Peoples R China

3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Minist Agr & Rural Affairs, Guangdong Lab Lingnan Modern Agr,Genome Anal Lab,S, Shenzhen, Peoples R China

关键词： cell Disk; codec algorithm; DNA data storage; random reading and rewriting

期刊名称：ADVANCED SCIENCE （ 影响因子：15.1； 五年影响因子：16.7 ）

ISSN：

年卷期： 2024 年

页码：

收录情况： SCI

摘要： DNA has emerged as an appealing material for information storage due to its great storage density and durability. Random reading and rewriting are essential tasks for practical large-scale data storage. However, they are currently difficult to implement simultaneously in a single DNA-based storage system, strongly limiting their practicability. Here, a "Cell Disk" storage system is presented, achieving high-density in vivo DNA data storage that enables both random reading and rewriting. In this system, each yeast cell is used as a chamber to store information, similar to a "disk block" but with the ability to self-replicate. Specifically, each genome of yeast cell has a customized CRISPR/Cas9-based "lock-and-key" module inserted, which allows selective retrieval, erasure, or rewriting of the targeted cell "block" from a pool of cells ("disk"). Additionally, a codec algorithm with lossless compression ability is developed to improve the information density of each cell "block". As a proof of concept, target-specific reading and rewriting of the compressed data from a mimic cell "disk" comprising up to 105 "blocks" are demonstrated and achieve high specificity and reliability. The "Cell Disk" system described here concurrently supports random reading and rewriting, and it should have great scalability for practical data storage use. A novel "Cell Disk" DNA storage system, which engineers yeast cells as addressable chambers to store high-density DNA-encoded information, concurrently supports random reading and rewriting, making it promising for a variety of large-scale data storage applications. image

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