Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius
文献类型： 外文期刊
作者： Wang, Siruo 1 ; Tai, Bowen 1 ; Yu, Xifan 1 ; Li, Erfeng 2 ; Wang, Gang 1 ; Jin, Jing 1 ; Xing, Fuguo 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Key Lab Agroprod Qual & Safety Control Storage & T, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China
2.Tianjin Agr Univ, Coll Hort & Landscape, Tianjin 300384, Peoples R China
关键词：
期刊名称：TOXINS （ 影响因子：4.0； 五年影响因子：4.5 ）
ISSN：
年卷期： 2025 年 17 卷 7 期
页码：
收录情况： SCI
摘要： Aspergillus carbonarius is one of the main pathogens responsible for postharvest diseases in fruits and is also one of the main ochratoxin A-producing strains. It not only causes significant economic losses but also poses a risk to human health. We found an inhibitory effect of dimethyl fumarate fumigation on the growth of A. carbonarius. To further explore its antifungal mechanism, this study elucidated the functions of key pathway-related genes through a transcriptomics analysis. A total of 1402 differentially expressed genes (DEGs) were identified, including 987 up-regulated and 415 down-regulated genes. Dimethyl fumarate was found to significantly inhibit the growth of A. carbonarius by disrupting cell integrity and obstructing mycelium growth and secondary metabolism. These findings provide a basis for the potential application of dimethyl fumarate in the food industry to inhibit A. carbonarius and subsequent ochratoxin A contamination.
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