文献类型： 外文期刊
作者： Li, Yingrui 1 ; Chen, Ze 1 ; Guo, Jia 1 ; Meng, Deshuang 1 ; Pang, Xin 1 ; Sun, Zepeng 1 ; Pu, Li 1 ; Yang, Shuiyue 1 ; Yang, Min 1 ; Peng, Yinghua 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Jilin, Peoples R China
2.Changchun Univ Technol, Sch Chem & Life Sci, Changchun 130012, Jilin, Peoples R China
关键词： Cannabidiol; Exosomes; Brain-targeted delivery; Drug delivery; RVG
期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：2.5； 五年影响因子：2.7 ）
ISSN： 0006-291X
年卷期： 2024 年 725 卷
页码：
收录情况： SCI
摘要： This study introduces an innovative brain-targeted drug delivery system, RVG-Exo/CBD, utilizing rabies virus glycoprotein (RVG)-engineered exosomes for encapsulating cannabidiol (CBD). The novel delivery system was meticulously characterized, confirming the maintenance of exosomal integrity, size, and successful drug encapsulation with a high drug loading rate of 83.0 %. Evaluation of the RVG-Exo/CBD's brain-targeting capability demonstrated superior distribution and retention in brain tissue compared to unmodified exosomes, primarily validated through in vivo fluorescence imaging. The efficacy of this delivery system was assessed using a behavioral sensitization model in mice, where RVG-Exo/CBD notably suppressed methamphetamine-induced hyperactivity more effectively than CBD alone, indicating a reduction in effective dose and enhanced bioavailability. Overall, the RVG-Exo/CBD system emerges as a promising strategy for enhancing the therapeutic efficacy and safety of CBD, particularly for neurological applications, highlighting its potential for addressing the limitations associated with traditional CBD administration in clinical settings.
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