文献类型: 外文期刊
作者: Bai XingWen 1 ; Li PingHua 1 ; Bao HuiFang 1 ; Liu ZaiXin 1 ; Li Dong 1 ; Lu ZengJun 2 ; Cao YiMei; Shang YouJun; Shao 1 ;
作者机构: 1.Chinese Acad Agr Sci, Engn Res Ctr Biol Detect Gansu Prov, Natl Foot & Mouth Dis Reference Lab, State Key Lab Vet Etiol Biol,Lanzhou Vet Res Inst, Lanzhou 730046, Peoples R China
2.Chinese Acad Agr Sci, Engn Res Ctr Biol Detect Gansu Prov, Natl Foot & Mouth Dis Reference Lab, State Key Lab Vet Etiol Biol
关键词: foot-and-mouth disease virus;phylogenetic analysis;recombination;positive selection
期刊名称:CHINESE SCIENCE BULLETIN ( 影响因子:1.649; 五年影响因子:1.738 )
ISSN: 1001-6538
年卷期: 2011 年 56 卷 21 期
页码:
收录情况: SCI
摘要: Foot-and-mouth disease (FMD), caused by foot-and-mouth disease virus (FMDV), is considered one of the most important viral diseases of cloven-hoofed animals, causing severe economic losses in affected regions of the world. Three serotypes (A, O, and Asia 1) of FMDV have been identified in China since 1958. In addition, the occurrence of novel subtypes within these serotypes has made the epidemiology of FMDV more complicated over the last few years. In this review, we summarize the history and the current epidemiological situation in China, genetic diversity (e.g., quasispecies dynamics, antigenic heterogeneity, and functional constraints), intertypic recombination, and the evidence for positive selection of different FMDV serotypes. We also assess these genetic data to understand the origin, evolution, and transmission of FMDV, the findings of which may be useful in developing control measures for future epidemics.
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