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Gut pathobiome mediates behavioral and developmental disorders in biotoxin-exposed amphibians

文献类型： 外文期刊

作者： Pan, Qianqian 1 ; Lv, Tianxing 1 ; Xu, Haorong 1 ; Fang, Hongda 1 ; Li, Meng 2 ; Zhu, Jiaping 2 ; Wang, Yue 1 ; Fan, Xiaoyan 1 ; Xu, Ping 3 ; Wang, Xiuguo 4 ; Wang, Qiangwei 1 ; Matsumoto, Haruna 1 ; Wang, Mengcen 1 ;

作者机构： 1.Zhejiang Univ, Rural Affairs Lab Mol Biol Crop Pathogens & Insect, Minist Agr, Hangzhou 310058, Peoples R China

2.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Coll Agr & Biotechnol, Hangzhou 310058, Peoples R China

3.Zhejiang Univ, Inst Tea Sci, Hangzhou 310058, Peoples R China

4.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China

5.Hokkaido Univ, Grad Sch Agr, Global Educ Program Agrisci Frontiers, Sapporo, Japan

关键词： Gut microbiome; Pathobiome; Biotoxin pollution; Developmental toxicity; Behavioral disorders

期刊名称：ENVIRONMENTAL SCIENCE AND ECOTECHNOLOGY （ 影响因子：12.6； 五年影响因子：12.6 ）

ISSN： 2666-4984

年卷期： 2024 年 21 卷

页码：

收录情况： SCI

摘要： Emerging evidence suggests a link between alterations in the gut microbiome and adverse health outcomes in the hosts exposed to environmental pollutants. Yet, the causal relationships and underlying mechanisms remain largely undefined. Here we show that exposure to biotoxins can affect gut pathobiome assembly in amphibians, which in turn triggers the toxicity of exogenous pollutants. We used Xenopus laevis as a model in this study. Tadpoles exposed to tropolone demonstrated notable developmental impairments and increased locomotor activity, with a reduction in total length by 4.37%-22.48% and an increase in swimming speed by 49.96%-84.83%. Fusobacterium and Cetobacterium are predominant taxa in the gut pathobiome of tropolone-exposed tadpoles. The tropolone-induced developmental and behavioral disorders in the host were mediated by assembly of the gut pathobiome, leading to transcriptome reprogramming. This study not only advances our understanding of the intricate interactions between environmental pollutants, the gut pathobiome, and host health but also emphasizes the potential of the gut pathobiome in mediating the toxicological effects of environmental contaminants. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Society for Environmental Sciences, Harbin Institute of Technology, Chinese Research Academy of Environmental Sciences. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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