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Genetic variability, evidence of potential recombinational event and selection of LEI0258 in chicken

文献类型： 外文期刊

作者： E, Guangxin 1 ; Sha, Rinai 1 ; Zeng, Shengcheng 1 ; Wang, Chen 1 ; Pan, Jianfei 2 ; Han, Jianlin 1 ;

作者机构： 1.CAAS, Key Lab Farm Anim Genet Resources & Utilizat, Inst Anim Sci, Minist Agr, Beijing 100193, Peoples R China

2.GAU, Coll Anim Sci & Technol, Lanzhou 730070, Peoples R China

关键词： Major histocompatibility complex;LEI0258;Chicken;Evolution

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： The chicken major histocompatibility complex (MHC) plays an important role in the immune response, disease resistance, productivity, and other important economic traits of the chicken. Therefore, a description of the polymorphisms of this region is crucial for understanding the genetic pattern of the MHC. The tandem repeat LEI0258 is located within the B region of the chicken MHC and is surprisingly strongly associated with serology. This marker has been used worldwide to provide a picture of the core area of the chicken MHC-B region and to categorize chicken MHC haplotypes. Thus, insight into the evolutionary pattern of LEI0258 may be useful for understanding MHC diversity.In the current study, 30 alleles of LE10258 from 12 populations were screened and sequenced, and alleles that have previously been published in GenBank were also analyzed. The resulting 124 alleles were classified into four clusters according to the SNPs and indels found within the sequences flanking the repeats. Furthermore, a recombination region was identified between -30 and +43 that suggests that recombination may have played a role in the evolution of this MHC. Finally, strong evidence regarding the selection and evolutionary dynamics of the LEI0258 region is presented.Generally speaking, microsatellite is a classic anonymous marker which changes by genetic drift rather than by direct selection. Although, the genotypes of LEI0258 in MHC-B correlate with serology, its mechanism of inheritance and evolution was unclear. This study not only establishes a framework of further diversity or association studies in LE10258, but also unraveling the reason what driving force and formulate the evolutionary dynamics of this region.

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