Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation
文献类型： 外文期刊
作者： Xin, Tongxu 1 ; Zhang, Zhen 2 ; Zhang, Yueying 4 ; Li, Xutong 1 ; Wang, Shenhao 1 ; Wang, Guanqun 5 ; Li, Haoxuan 5 ; Wang, Bowen 1 ; Zhang, Mengzhuo 1 ; Li, Wenjing 1 ; Tian, Haojie 1 ; Zhang, Zhonghua 6 ; Xiao, Yu-Lan 7 ; Tang, Weixin 7 ; He, Chuan 1 ; Ding, Yiliang 4 ; Huang, Sanwen 2 ; Yang, Xueyong 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Vegetables & Flowers, State Key Lab Vegetable Biobreeding, Beijing, Peoples R China
2.Chinese Acad Agr Sci, Guangdong Lab Lingnan Modern Agr, Genome Anal Lab,Minist Agr & Rural Affairs, Shenzhen Branch,Agr Genom Inst Shenzhen, Shenzhen 518120, Guangdong, Peoples R China
3.Henan Univ, Coll Agr, State Key Lab Crop Stress Adaptat & Improvement, Jinming Ave 1, Kaifeng 475004, Peoples R China
4.John Innes Ctr, Dept Cell & Dev Biol, Norwich Res Pk, Norwich NR4 7UH, England
5.Univ Chicago, Inst Biophys Dynam, Dept Biochem & Mol Biol, Howard Hughes Med Inst,Dept Chem, Chicago, IL 60637 USA
6.Qingdao Agr Univ, Coll Hort, Engn Lab Genet Improvement Hort Crops Shandong Pro, Qingdao 266109, Peoples R China
7.Univ Chicago, Dept Chem, Chicago, IL 60637 USA
8.Univ Chicago, Inst Biophys Dynam, Chicago, IL USA
期刊名称：CELL （ 影响因子：42.5； 五年影响因子：48.9 ）
ISSN： 0092-8674
年卷期： 2025 年 188 卷 17 期
页码：
收录情况： SCI
摘要： Synonymous mutations, once known as "silent"mutations, are increasingly attracting the interest of biologists. Although they may affect transcriptional or post-transcriptional processes, their impact on biological traits remains under-investigated, particularly at the organismal level. Here, we identified two closely linked, epistatically interacting genes: YTH1, an RNA N6-methyladenosine (m6A) reader, and ACS2, an aminocyclo-propane-1-carboxylic acid (ACC) synthase, which contribute to cucumber fruit length domestication. The causative mutation in ACS2 is a synonymous substitution at 1287C>T. In wild cucumber, ACS21287C results in m6A modification on nearby adenosine residues and the formation of loose RNA structural conformations. YTH1 recognizes the m6A modification, alters the folding equilibrium toward the weakest RNA structural conformation, and increases the ACS2 protein level, resulting in shorter fruit. In cultivated cucumber, ACS21287T disrupts m6A methylation and forms compact RNA structural conformations, leading to attenuated protein production and fruit elongation. This study provides genetic evidence of synonymous variation shaping a biological trait through epitranscriptomic regulations.
- 相关文献
作者其他论文 更多>>
-
Effect of crowding stress on liver health, gut permeability and gut microbiota of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
作者：Zhang, Jian;Chen, Jie;Liang, Hui;Li, Ming;Zhou, Wenhao;Zhou, Zhigang;Yang, Yalin;Zhang, Zhen;Ran, Chao;Ding, Qianwen
关键词：Crowing stress; Apoptosis; Gut permeability; Gut microbiota; GIFT
-
Leveraging a phased pangenome for haplotype design of hybrid potato
作者：Cheng, Lin;Wang, Nan;Bao, Zhigui;Yang, Yuting;Wang, Pei;Zhang, Zhiyang;Tang, Die;Zhang, Pingxian;Wu, Yaoyao;Zhou, Yao;Zheng, Yi;Hu, Yong;Lian, Qun;Ma, Zhaoxu;Zhang, Chunzhi;Zhou, Yongfeng;Huang, Sanwen;Cheng, Lin;Lassois, Ludivine;Wang, Nan;Zhou, Yongfeng;Huang, Sanwen;Bao, Zhigui;Zhou, Qian;Guarracino, Andrea;Garrison, Erik;Tang, Die;Wu, Yaoyao;Zhou, Yao;Lucas, William J.;Stein, Nils;Stein, Nils;Staedler, Thomas;Staedler, Thomas
关键词：
-
Enhancing genetic transformation efficiency in cucurbit crops through AtGRF5 overexpression: Mechanistic insights and applications
作者：Li, Yang;Wang, Naonao;Feng, Jing;Liu, Yue;Wang, Huihui;Deng, Shijun;Dong, Wenjing;Liu, Xiaofeng;Lv, Bingsheng;Xu, Kuipeng;Zhang, Huimin;Zhang, Zhonghua;Chai, Sen;Sun, Jinjing
关键词：auxin; cucurbit crops; genetic transformation; GRF; regeneration; scRNA-Seq
-
Melon2K array: A versatile 2K liquid SNP chip for melon genetics and breeding
作者：Yu, Qing;Su, Xiaofeng;Chen, Xinxiu;Dong, Yuanhua;Yao, Zhiwang;Jiang, Naiyu;Chai, Sen;Zhang, Zhonghua;Xu, Kuipeng;Zhang, Zhonghua;Zhang, Zhonghua;Zhang, Zhonghua;Li, Shuai;Li, Shuai
关键词：Melon; Cucumis melo L.; Melon2K; Liquid SNP chip; Cultivar identification; Background selection
-
Developmental innovation of inferior ovaries and flower sex orchestrated by KNOX1 in cucurbits
作者：Dong, Zhaonian;Liu, Xiaolin;Liu, Xun;Wang, Bowen;Tian, Caihuan;Zheng, Yingying;Yu, Qiong;Sun, Jinjing;Xin, Tongxu;Yang, Xueyong;Dong, Zhaonian;Wang, Bowen;Huang, Sanwen;Guo, Xing;Shao, Wenwen;Zhong, Liyuan;Shao, Wenwen;Zhong, Liyuan;Li, Shengkang;Zhang, Bohan;Xu, Xun;Liu, Huan;Shao, Wenwen;Tian, Caihuan;Yang, Tao;Lu, Haorong;Rose, Jocelyn K. C.;Lucas, William J.;Huang, Sanwen
关键词：
-
The genomic and epigenomic landscapes of hemizygous genes across crops with contrasting reproductive systems
作者：Peng, Yanling;Wang, Yiwen;Liu, Yuting;Fang, Xinyue;Cheng, Lin;Long, Qiming;Su, Dalu;Zhang, Tianhao;Shi, Xiaoya;Xu, Xiaodong;Xu, Qi;Wang, Nan;Zhang, Fan;Liu, Zhongjie;Xiao, Hua;Huang, Sanwen;Zhou, Yongfeng;Yao, Jin;Tian, Ling;Hu, Wei;Chen, Songbi;Huang, Sanwen;Zhou, Yongfeng;Wang, Haibo;Gaut, Brandon S.
关键词：grapevine; clonal propagation; structural variation; integrative genomics; heterozygosity
-
A fishy gut feeling - current knowledge on gut microbiota in teleosts
作者：Tolas, Ingvill;Ronnestad, Ivar;Tolas, Ingvill;Zhou, Zhigang;Zhang, Zhen;Teame, Tsegay;Zhang, Zhen;Teame, Tsegay;Olsen, Rolf Erik;Ringo, Einar
关键词：gut microbiota; metabolism; fish diet; aquaculture; gut-brain axis; teleosts
