Inactivation of β-1,3-glucan synthase-like 5 confers broad-spectrum resistance to Plasmodiophora brassicae pathotypes in cruciferous plants
文献类型： 外文期刊
作者： Wu, Yupo 1 ; Zhao, Chuanji 1 ; Zhang, Yi 1 ; Shen, Cuicui 1 ; Zhang, Yuanyuan 1 ; Zhang, Xiong 1 ; Gao, Lixia 1 ; Zeng, Lingyi 1 ; Ke, Qinglin 1 ; Qin, Li 1 ; Liu, Fan 1 ; Huang, Junyan 1 ; Ren, Li 1 ; Liu, Yueying 1 ; Cheng, Hongtao 1 ; Tong, Chaobo 1 ; Hu, Qiong 1 ; Cheng, Xiaohui 1 ; Wei, Yangdou 3 ; Liu, Shengyi 1 ; Liu, Lijiang 1 ;
作者机构： 1.Chinese Acad Agr Sci, Minist Agr & Rural Affairs, Oil Crops Res Inst, Key Lab Biol & Genet Improvement Oil Crops, Wuhan, Peoples R China
2.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Peoples R China
3.Univ Saskatchewan, Dept Biol, Saskatoon, SK, Canada
期刊名称：NATURE GENETICS （ 影响因子：29.0； 五年影响因子：37.4 ）
ISSN： 1061-4036
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Clubroot disease, caused by the obligate intracellular rhizarian protist Plasmodiophora brassicae, is devastating to cruciferous crops worldwide. Widespread field P. brassicae pathotypes frequently overcome the pathotype-specific resistance of modern varieties, posing a challenge for durable control of this disease. Here a genome-wide association study of 3 years of data comprising field clubroot phenotyping of 244 genome-resequenced Brassica napus accessions identified a strong association of beta-1,3-glucan synthase-like 5 (GSL5) with clubroot susceptibility. GSL5 was evolutionarily conserved, and inactivation of GSL5 by genome editing in Arabidopsis, B. napus, Brassicarapa and Brassica oleracea conferred broad-spectrum, high-level resistance to P. brassicae pathotypes without yield penalties in B. napus. GSL5 inactivation derepressed the jasmonic acid-mediated immunity during P. brassicae secondary infection, and this immune repression was possibly reinforced through stabilization of GSL5 by a P. brassicae effector, facilitating clubroot susceptibility. Our study provides durable resistance resources for cruciferous clubroot disease control and insights into plant resistance against intracellular eukaryotic phytopathogens.
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