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Pralatrexate effectively inhibits the replication of monkeypox virus in vitro and in vivo

文献类型： 外文期刊

作者： Li, Jianshu 1 ; Li, Siyu 1 ; Gu, Chaode 1 ; Shi, Shaowen 4 ; Li, Xiao 4 ; Guo, Zhendong 4 ; Zhao, Zongzheng 4 ; He, Miao 2 ; Wu, Zhiwei 1 ;

作者机构： 1.Nanjing Univ, Med Sch, Ctr Publ Hlth Res, Nanjing, Peoples R China

2.Dali Univ, Coll Pharm, Yunnan Prov Key Lab Entomol Biopharmaceut R&D, Dali, Yunnan, Peoples R China

3.Nanjing Univ, Med Sch, State Key Lab Analyt Chem Life Sci & Jiangsu Key L, Nanjing 210093, Peoples R China

4.Chinese Acad Agr Sci, Changchun Vet Res Inst, State Key Lab Pathogen & Biosecur, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130118, Peoples R China

关键词： Pralatrexate; MPXV; Antiviral; Poxviruses

期刊名称：ANTIVIRAL RESEARCH （ 影响因子：4.0； 五年影响因子：4.3 ）

ISSN： 0166-3542

年卷期： 2025 年 241 卷

页码：

收录情况： SCI

摘要： The monkeypox virus (MPXV), an orthopoxvirus, has caused a number of major outbreaks and emerged as a global public health threat. Although drugs have been approved for the treatment of mpox, the efficacy and side effects remain unknown, which calls for the development of safe and effective drugs. Pralatrexate (PDX) is a fourth-generation antifolate drug with inhibitory activity against a wide range of viruses. In this study, we demonstrated the antiviral activity of PDX against MPXV in vitro and in vivo. Our results showed that PDX potently inhibited the MPXV replication at very low drug concentrations in vitro, and could significantly inhibit MPXV activity in dormice. In conclusion, this study found that PDX is an effective antiviral drug against MPXV infection, showing potential as a novel therapy for MPXV infection.

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