Supramolecular lipopeptidic adjuvant regulates protective abilities of MPXV subunit vaccine against monkeypox virus
文献类型： 外文期刊
作者： Bao, Wenxin 1 ; Zhang, Yanwen 1 ; Shang, Chao 2 ; Jin, Zhedong 1 ; Zhu, Yilong 3 ; Dai, Lili 4 ; Cui, Caixia 1 ; Li, Huiyi 1 ; Wei, Jiangbo 5 ; Li, Xiao 2 ; Zhu, Jianwei 1 ; Wang, Yin 1 ; Yuan, Yunsheng 1 ;
作者机构： 1.Shanghai Jiao Tong Univ, Sch Pharm, Engn Res Ctr Cell & Therapeut Antibody, Minist Educ, Shanghai 200240, Peoples R China
2.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Peoples R China
3.Changchun Univ Chinese Med, Academicians Workstat Jilin Prov, Changchun 130117, Peoples R China
4.Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing 100069, Peoples R China
5.Natl Vaccine & Serum Inst, Beijing 101111, Peoples R China
关键词： Self-assembly; Lipopeptides; MPXV; Vaccine adjuvants
期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.2； 五年影响因子：13.5 ）
ISSN： 1385-8947
年卷期： 2025 年 507 卷
页码：
收录情况： SCI
摘要： Recombinant antigens have been used for vaccine development, which need suitable adjuvants to boost the immunogenicity. To this end, we report here our discovery on rationally designed lipopeptide amphiphiles could be applied for adjuvants. After accompanying with lipopeptidic adjuvants, multi-antigens subunit vaccines consisting of mature virus and enveloped virus surface proteins exhibited good immunogenicity and effectively elicited humoral immune response. Both structural screening and in vitro studies demonstrated that among these adjuvants, C16-GCV2E3, one of self-assembling lipopeptides with the palmitic acid capped on N terminus, could significantly enhance the antigen uptake, DC maturation, and T cell responses with Th2 skewing. Notably, in vivo results further confirmed that C16-GCV2E3 augmented the titer of antigen-specific antibodies, enhanced the neutralizing activity of immune serum to MPXV, and boosted efficacy of the subunit vaccine against VACV compared to several counterparts in mice. We believe our discovery opens a new avenue for the development of effective adjuvants.
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