文献类型： 外文期刊
作者： Huang, Jia 1 ; He, Bingbing 1 ; Yang, Xiali 3 ; Long, Xin 4 ; Wei, Yinghui 2 ; Li, Leijie 1 ; Tang, Min 6 ; Gao, Yanxia 2 ; Fang, Yuan 2 ; Ying, Wenqin 2 ; Wang, Zikang 2 ; Li, Chao 2 ; Zhou, Yingsi 2 ; Li, Shuaishuai 1 ; Shi, Linyu 7 ; Choi, Seungwon 2 ; Zhou, Haibo 2 ; Guo, Fan 4 ; Yang, Hui 2 ; Wu, Jun 1 ;
作者机构： 1.Univ Texas Southwestern Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
2.Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai 200031, Peoples R China
3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Key Lab Livestock & Poultry Multiom MARA, Shenzhen Branch,Guangdong Lab Lingnan Modern Agr, Shenzhen 518000, Peoples R China
4.Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
6.Univ Texas Southwestern Med Ctr, Dept Psychiat, Dallas, TX 75390 USA
7.Huidagene Therapeut Co Ltd, Shanghai 200131, Peoples R China
8.Univ Texas Southwestern Med Ctr, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA
9.Univ Texas Southwestern Med Ctr, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA
期刊名称：CELL （ 影响因子：64.5； 五年影响因子：57.5 ）
ISSN： 0092-8674
年卷期： 2024 年 187 卷 9 期
页码：
收录情况： SCI
摘要： Interspecies blastocyst complementation (IBC) provides a unique platform to study development and holds the potential to overcome worldwide organ shortages. Despite recent successes, brain tissue has not been achieved through IBC. Here, we developed an optimized IBC strategy based on C-CRISPR, which facilitated rapid screening of candidate genes and identified that Hesx1 deficiency supported the generation of rat forebrain tissue in mice via IBC. Xenogeneic rat forebrain tissues in adult mice were structurally and functionally intact. Cross -species comparative analyses revealed that rat forebrain tissues developed at the same pace as the mouse host but maintained rat -like transcriptome profiles. The chimeric rate of rat cells gradually decreased as development progressed, suggesting xenogeneic barriers during mid -to -late pre -natal development. Interspecies forebrain complementation opens the door for studying evolutionarily conserved and divergent mechanisms underlying brain development and cognitive function. The C-CRISPR-based IBC strategy holds great potential to broaden the study and application of interspecies organogenesis.
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