Research note: Unveiling the impact of ovotransferrin on chicken primordial germ cells biological processes
文献类型： 外文期刊
作者： Liu, Xin 1 ; Peng, Yixiu 1 ; Wu, Jun 1 ; Qian, Hongwu 1 ; Lv, Xiaoqian 1 ; Li, Fan 1 ; Jin, Kai 1 ; Niu, Yingjie 1 ; Song, Jiuzhou 4 ; Han, Wei 5 ; Chen, Guohong 1 ; Li, Bichun 1 ; Zuo, Qisheng 1 ;
作者机构： 1.Yangzhou Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Mol Design Jiangsu P, Yangzhou 225009, Peoples R China
2.Yangzhou Univ, Inst Agr Sci & Technol Dev, Yangzhou 225009, Peoples R China
3.Yangzhou Univ, Joint Int Res Lab Agr & Agriprod Safety, Minist Educ China, Yangzhou 225009, Peoples R China
4.Univ Maryland, Anim & Avian Sci, College Pk, MA 20742 USA
5.Chinese Acad Agr Sci, Poultry Inst, Poultry Inst Jiangsu, Yangzhou 225003, Peoples R China
6.Jiangsu Univ Sci & Technol, Coll Biotechnol, Zhenjiang 212100, Peoples R China
关键词： Chicken; Primordial germ cell; ovotransferrin; chicken; serum
期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）
ISSN： 0032-5791
年卷期： 2025 年 104 卷 7 期
页码：
收录情况： SCI
摘要： In the field of genetic breeding, primordial germ cells (PGCs) have become essential cells for gene editing and genetic improvement due to their unique developmental potential and genetic characteristics. However, the low proliferation efficiency and instability of culture systems pose significant challenges, severely limiting the application of PGCs in genetic breeding. In this study, the biological effects of ovotransferrin on chicken PGCs, focusing on its role in regulating key cellular processes. Treatment with 0.5 mg/ml ovotransferrin significantly promoted cell proliferation, enhanced cell adhesion, reduced oxidative stress, and suppressed apoptosis in cultured PGCs. These findings reveal a regulatory role of ovotransferrin in maintaining PGCs survival and function, providing new insights into optimizing PGC culture systems through targeted modulation of cell fate.
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