文献类型： 外文期刊
作者： Luo, Rongbo 1 ; Shen, Beilei 1 ; Qian, Bingshuo 1 ; Fan, Lingjun 1 ; Zhang, Junkui 1 ; Deng, Xiuwen 1 ; Sun, Yan 1 ; Zhang, Shijun 1 ; Wang, Tiecheng 1 ; Li, Yuanguo 1 ; Sun, Weiyang 1 ; Pang, Xiaobin 2 ; Zhong, Wu 7 ; Gao, Yuwei 1 ;
作者机构： 1.Chinese Acad Agr Sci, Changchun Vet Res Inst, State Key Lab Pathogen & Biosecur, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China
2.Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China
3.Northeast Normal Univ, Engn Res Ctr Glycoconjugates, Jilin Prov Key Lab Chem & Biol Changbai Mt Nat Dru, Sch Life Sci,Minist Educ, Changchun 130024, Peoples R China
4.Changchun Univ Chinese Med, Coll Integrated Chinese & Western Med, Changchun 130117, Jilin, Peoples R China
5.Shanxi Agr Univ, Coll Vet Med, Jinzhong 030801, Peoples R China
6.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China
7.Beijing Inst Pharmacol & Toxicol, Natl Engn Res Ctr Emergency Drug, Beijing 100850, Peoples R China
关键词： SARS-CoV-2; Influenza virus; Antiviral; Lung injury; Taurultam; Taurolidine metabolite
期刊名称：BMC MICROBIOLOGY （ 影响因子：4.2； 五年影响因子：4.8 ）
ISSN： 1471-2180
年卷期： 2025 年 25 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundSARS-CoV-2 and influenza virus are highly contagious respiratory viruses that continuously pose major threats to human and public health. The high frequency of viral mutations led to the emergence of resistant isolates and caused virus epidemics repeatedly, emphasizing the urgent need to develop new antivirals. Taurultam is a metabolite of taurolidine. Moreover, taurolidine has been shown to have potent antiviral activities against multiple viruses and to have antiviral effects through its metabolites.ResultsIn this study, we sought to determine the antiviral activities of taurultam against SARS-CoV-2 and influenza virus in Vero-E6, Huh7, 293T-ACE2, and MDCK cell lines and mouse infection models. The results showed that taurultam exhibited potent antiviral activity against multiple SARS-CoV-2 variants, influenza A (H1N1, H3N2) virus and influenza B virus, in vitro. Moreover, in influenza A (H1N1) virus, influenza B virus and SARS-CoV-2 infection models, taurultam significantly reduced viral loads, increased survival, improved mouse body weight and lung injury. Surprisingly, taurultam treatment not only inhibited the influenza A virus and SARS-CoV-2, but also benefited for therapy of mixed infection of these two viruses in vitro, demonstrating the great antiviral potential of taurultam for the treatment of SARS-CoV-2 and influenza virus infections.ConclusionsTogether, our findings identify taurultam as a new candidate for the treatment of SARS-CoV-2 and influenza virus infections, especially virus-induced lung pathology.Clinical trial numberNot applicable.
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