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Taurolidine inhibits influenza virus infection and prevents influenza-induced cytokine storm, vasoconstriction and lung damage

文献类型： 外文期刊

作者： Lv, Chaoxiang 1 ; Guo, Jin 2 ; Luo, Rongbo 2 ; Li, Yuanguo 2 ; Qian, Bingshuo 2 ; Zou, Xiaopan 6 ; Wang, Tiecheng 2 ; Shen, Beilei 2 ; Sun, Weiyang 2 ; Gao, Yuwei 2 ;

作者机构： 1.Southwest Med Univ, Res Ctr Preclin Med, Luzhou 646000, Peoples R China

2.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Peoples R China

3.Southwest Med Univ, Sch Basic Med Sci, Luzhou 646000, Peoples R China

4.Shandong Normal Univ, Coll Life Sci, Jinan 250358, Peoples R China

5.Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China

6.Jilin Prov Peoples Hosp, Breast & Thyroid Surg, Changchun 130021, Jilin, Peoples R China

7.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Jilin, Peoples R China

关键词： Taurolidine; Vasoconstriction; Influenza virus; Calcium influx; MLCK/p-MLC signaling pathway

期刊名称：CELLULAR AND MOLECULAR LIFE SCIENCES （ 影响因子：6.2； 五年影响因子：7.7 ）

ISSN： 1420-682X

年卷期： 2025 年 82 卷 1 期

页码：

收录情况： SCI

摘要： Influenza virus causes worldwide outbreaks and seasonal epidemics, posing a severe threat to public health and social development. Effective prevention and treatment of influenza infections remain major challenge for global healthcare. In this study, we observed that taurolidine effectively inhibited the proliferation of several human or animal influenza virus strains and protected mice from lethal-infection. Taurolidine treatment decreased the viral titer in the lungs of infected mice, reduced the ratio of immune cells, and alleviated lung pathology. Additionally, taurolidine treatment attenuated the rise of blood pressure, pulse wave velocity, and pulmonary aortic thickness in a mouse model for influenza virus infection. We also found that taurolidine significantly decreased intracellular Ca2+ concentration and effectively alleviated pulmonary artery vasoconstriction during influenza virus infection. Mechanistically, we observed that vascular smooth muscle contraction signaling pathway was significantly enriched, and taurolidine inhibited the activation of the MLCK/p-MLC pathway. Taking together, these findings confirm the effectiveness of taurolidine as an antiviral agent and highlight its important roles in mitigating host immune cell infiltration and vasoconstriction induced by influenza virus infection.

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