Promotional activity of an uncharacterized protein Bm0979 on Nosema bombycis in silkworm, bombyx mori
文献类型： 外文期刊
作者： Fang, Yujia 1 ; Yu, Qiong 1 ; Chen, Wenzhe 1 ; Han, Zhenghao 1 ; Qu, Qingsheng 1 ; Jia, Zhenwei 1 ; Jiang, Shidong 2 ; Cheng, Jie 1 ; Tang, Xudong 1 ; Qian, Ping 1 ;
作者机构： 1.Jiangsu Univ Sci & Technol, Sch Biotechnol, Jiangsu Key Lab Sericultural Biol & Biotechnol, Zhenjiang 212100, Peoples R China
2.Guangxi Key Lab Sericultural Genet Improvement & E, Nanning 530007, Peoples R China
3.Chinese Acad Agr Sci, Sericultural Res Inst, Key Lab Silkworm & Mulberry Genet Improvement, Minist Agr & Rural Affairs, Zhenjiang 212100, Peoples R China
关键词： Bombyx mori; Microsporidia; Nosema bombycis; PI3K/Akt signaling; Host-pathogen interaction
期刊名称：JOURNAL OF ASIA-PACIFIC ENTOMOLOGY （ 影响因子：1.3； 五年影响因子：1.4 ）
ISSN： 1226-8615
年卷期： 2025 年 28 卷 2 期
页码：
收录情况： SCI
摘要： Microsporidia are intracellular parasites that infect a diverse range of hosts, including economically significant insects like the silkworm (Bombyx mori). In this study, we investigated the effects of the microsporidian pathogen Nosema bombycis (Nb) on B. mori, with a focus on the cloning and functional characterization of the gene Bm0979. Our findings indicate that Bm0979 has at least two isoforms and is significantly upregulated in response to Nb infection. Functional assays involving overexpression and knockdown of Bm0979 in silkworm cells revealed that this gene promotes Nb proliferation, identifying it as a potential target for enhancing silkworm resistance to pebrine disease. Transcriptome sequencing further revealed that Bm0979 modulates the expression of genes related to the PI3K/Akt signaling pathway, which is implicated in immune responses and cellular metabolism. These findings provide new insights into the molecular mechanisms underlying host-pathogen interactions in silkworms and could contribute to the development of strategies for controlling microsporidia infections in sericulture.
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