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Baculoviruses manipulate host lipid metabolism via adipokinetic hormone signaling to induce climbing behavior

文献类型： 外文期刊

作者： Zhu, Lin 1 ; Xie, Yuqing 1 ; Liu, Chenxi 1 ; Cheng, Jie 3 ; Shen, Zhongjian 4 ; Liu, Xiaoming 5 ; Cai, Limei 1 ; Ning, Xinyuan 1 ; Zhang, Songdou 1 ; Li, Zhen 1 ; Huang, Qiuying 6 ; Liu, Xiaoxia 1 ;

作者机构： 1.China Agr Univ, Coll Plant Protect, Dept Entomol, Beijing, Peoples R China

2.China Agr Univ, Coll Plant Protect, MOA Key Lab Pest Monitoring & Green Management, Beijing, Peoples R China

3.Shanxi Agr Univ, Dept Entomol Coll Plant Protect, Jinzhong, Peoples R China

4.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Key Lab Nat Enemy Insects,Minist Agr & Rural Affai, Beijing, Peoples R China

5.Henan Agr Univ, Coll Plant Protect, State Key Lab Wheat & Maize Crop Sci, Henan Int Lab Green Pest Control, Zhengzhou, Peoples R China

6.Huazhong Agr Univ, Hubei Insect Resources Utilizat & Sustainable Pest, Wuhan, Peoples R China

期刊名称：PLOS PATHOGENS （ 影响因子：4.9； 五年影响因子：5.4 ）

ISSN： 1553-7366

年卷期： 2025 年 21 卷 1 期

页码：

收录情况： SCI

摘要： Baculoviruses can induce climbing behavior in caterpillar hosts, which provides an excellent model for studying parasite manipulation of host behavior. Herein, we found that Helicoverpa armigera single nucleopolyhedrovirus (HearNPV) promoted lipid metabolism of infected H. armigera larvae, and changes in lipid metabolism can affect climbing behavior. Therefore, understanding the molecular mechanisms between lipid metabolism and climbing behavior is particularly important. In this study, we found adipokinetic hormone 1 (HaAKH1), adipokinetic hormone 2 (HaAKH2) and their receptor HaAKHR were essential for promoting lipid metabolism and climbing behavior in response to HearNPV infection. Both molecular docking result and Ca2+ imaging showed that both HaAKH1 and HaAKH2 could interact with HaAKHR. Knockdown of HaAKH1, HaAKH2 and HaAKHR resulted in not only the accumulation of triacylglycerol (TAG), but also the reduction of the replication of HearNPV and the crawling ability of infected H. armigera larvae, resulting in a decrease in the final death height of the infected larvae. We further validated this conclusion by injecting active peptides of HaAKH1 and HaAKH2 to infected larvae. In addition, we investigated the downstream of HaAKH signaling and found that hormone-sensitive lipase (HaHSL) changed with changes in HaAKH signaling and HaHSL played the same role as HaAKH signaling. These findings not only revealed the mechanism by which parasites manipulated host lipid metabolism, but more significantly, explored the relationship between lipid metabolism and behavioral changes of hosts manipulated by parasites, broadening our understanding of the phenomenon of parasites manipulating host behavioral changes.

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