The genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation
文献类型： 外文期刊
作者： Zan, Yanjun 1 ; Chen, Shuai 1 ; Ren, Min 1 ; Liu, Guoxiang 1 ; Liu, Yutong 1 ; Han, Yu 2 ; Dong, Yang 4 ; Zhang, Yao 4 ; Si, Huan 1 ; Liu, Zhengwen 1 ; Liu, Dan 1 ; Zhang, Xingwei 1 ; Tong, Ying 1 ; Li, Yuan 1 ; Jiang, Caihong 1 ; Wen, Liuying 1 ; Xiao, Zhiliang 1 ; Sun, Yangyang 1 ; Geng, Ruimei 1 ; Ji, Yan 1 ; Feng, Quanfu 1 ; Wang, Yuanying 1 ; Ye, Guoyou 8 ; Fang, Lingzhao 10 ; Chen, Yong 11 ; Cheng, Lirui 1 ; Yang, Aiguo 1 ;
作者机构： 1.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao, Peoples R China
2.Sichuan Univ, Coll Life Sci, Key Lab Bioresource & Ecoenvironm, Minist Educ, Chengdu, Peoples R China
3.Sichuan Univ, Coll Life Sci, Sichuan Zoige Alpine Wetland Ecosyst Natl Observat, Chengdu, Peoples R China
4.Chinese Acad Sci, Inst Bot, State Key Lab Plant Divers & Specialty Crops, Beijing, Peoples R China
5.China Natl Bot Garden, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Umea Univ, Umea Plant Sci Ctr, Dept Plant Physiol, Umea, Sweden
8.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, CAAS IRRI Joint Lab Genom Assisted Germplasm Enhan, Shenzhen, Peoples R China
9.Int Rice Res Inst, Strateg Innovat Platform, Manila, Philippines
10.Aarhus Univ, Ctr Quantitat Genet & Genom, Aarhus, Denmark
11.Beijing Life Sci Acad, Beijing, Peoples R China
期刊名称：NATURE GENETICS （ 影响因子：29.0； 五年影响因子：37.4 ）
ISSN： 1061-4036
年卷期： 2025 年 57 卷 4 期
页码：
收录情况： SCI
摘要： Nicotiana tabacum is an allotetraploid hybrid of Nicotiana sylvestris and Nicotiana tomentosiformis and a model organism in genetics. However, features of subgenome evolution, expression coordination, genetic diversity and complex traits regulation of N. tabacum remain unresolved. Here we present chromosome-scale assemblies for all three species, and genotype and phenotypic data for 5,196 N. tabacum germplasms. Chromosome rearrangements and epigenetic modifications are associated with genome evolution and expression coordination following polyploidization. Two subgenomes and genes biased toward one subgenome contributed unevenly to complex trait variation. Using 178 marker-trait associations, a reference genotype-to-phenotype map was built for 39 morphological, developmental and disease resistance traits, and a novel gene regulating leaf width was validated. Signatures of positive and polygenic selection during the process of selective breeding were detected. Our study provides insights into genome evolution, complex traits regulation in allotetraploid N. tabacum and the use of GeneBank-scale resources for advancing genetic and genomic research.
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