Miquelianin inhibits IAV infection via the MAPK signaling pathway both in vitro and in vivo
文献类型： 外文期刊
作者： Li, He 1 ; Shen, Beilei 2 ; Bi, Yan 1 ; Sun, Yan 3 ; Zhang, Shijun 1 ; Xue, Kun 2 ; Wang, Qiuyue 4 ; Qian, Bingshuo 5 ; Zhang, Junkui 5 ; Fan, Lingjun 6 ; Fang, Zhengyuan 1 ; Wang, Tiecheng 2 ; Gao, Yuwei 2 ; Yue, Donghui 1 ;
作者机构： 1.Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun, Peoples R China
2.Chinese Acad Agr Sci, Changchun Vet Res Inst, State Key Lab Pathogen & Biosecur, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China
3.Shanxi Agr Univ, Coll Vet Med, Jinzhong, Peoples R China
4.Hainan Med Univ, Coll Tradit Chinese Med, Haikou, Hainan, Peoples R China
5.Henan Univ, Sch Pharm, Kaifeng, Peoples R China
6.Northeast Normal Univ, Engn Res Ctr Glycoconjugates,Minist Educ, Sch Life Sci, Jilin Prov Key Lab Chem & Biol Changbai Mt Nat Dru, Changchun, Peoples R China
关键词： influenza A virus; flavonoids; miquelianin; network pharmacology; MAPK signaling pathway
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：5.9； 五年影响因子：6.8 ）
ISSN： 1664-3224
年卷期： 2025 年 16 卷
页码：
收录情况： SCI
摘要： Background Influenza is an acute respiratory infectious disease primarily transmitted through airborne droplets. The prevalence and spread of influenza viruses have significant impacts on global economic development and public health. Current prevention and control strategies for influenza virus infections mainly rely on vaccines and antiviral drugs. However, vaccine efficacy is limited by the antigenic drift and mutation characteristics of influenza viruses, while antiviral drug resistance is increasingly prevalent. Therefore, there is an urgent need for the development of novel antiviral agents. Flavonoids, widely distributed in plants, possess various potent biological properties, including antioxidant, anti-inflammatory, antibacterial, and anticancer activities, which contribute to the management and prevention of numerous diseases. This study aims to investigate the in vitro and in vivo anti-influenza A virus activity of quercetin, taxifolin, and miquelianin, as well as their underlying.Methods In vitro infection model (MDCK cells) and mouse lethal infection model of Infuenza A virus were used to evaluate the antiviral activity of quercetin, taxifolin and miquelianin. Subsequently, we applied network pharmacology to elucidate the mechanism of action and validate the findings for miquelianin.Results Miquelianin effectively inhibits the replication of H1N1-UI182 both in vitro and in vivo and provides protection against lethal H1N1-UI182 infection in mice. Compared to virus-infected controls, miquelianin reduces lung injury. Furthermore, by inhibiting the MAPK signaling pathway, miquelianin prevents the overproduction of cytokines, such as IL-6 and IL-1 beta, induced by viral infection, thereby alleviating inflammatory responses.Conclusion Miquelianin is a monomer extracted from traditional Chinese medicine, exhibiting inhibitory effects on H1N1-UI182 replication and lung injury mitigation.
- 相关文献
作者其他论文 更多>>
-
A surrogate BSL2-compliant infection model recapitulating key aspects of human Marburg virus disease
作者：Yang, Wanying;Zhou, Wujie;Liang, Bo;Hu, Xiaojun;Wang, Shen;Wang, Zhenshan;Wang, Tiecheng;Xia, Xianzhu;Feng, Na;Zhao, Yongkun;Yan, Feihu;Yang, Wanying;Hu, Xiaojun;Wang, Zhenshan
关键词：Marburg virus; recombinant vesicular stomatitis virus; Syrian hamster; surrogate model; recurrence of classic symptoms; vaccine evaluation and drug screening
-
An inactivated influenza D virus vaccine protects guinea pigs from infections and contact transmission caused by homologous challenge
作者：Dong, Zhipeng;Gao, Hongbo;Wang, Tiecheng;Xia, Xianzhu;Sun, Weiyang;Gao, Yuwei;Dong, Zhipeng;Lu, Pengyang;Wang, Tiecheng;Xia, Xianzhu;Feng, Yue;Wan, Wentao
关键词：Influenza D virus; Inactivated vaccine; Contact transmission; Guinea pigs
-
EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research
作者：Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang
关键词：metagenome; microbiome; microbiota; pipeline; visualization
-
Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation
作者：Sun, Yan;Yan, Fang;Sun, Yan;Wu, Jiajing;Shen, Beilei;Luo, Rongbo;Zhang, Shijun;Li, He;Qian, Bingshuo;Fan, Lingjun;Zhang, Junkui;Wang, Tiecheng;Xia, Xianzhu;Gao, Yuwei;Yang, Hengzheng;Cui, Huizi;Han, Weiwei;Xia, Xianzhu
关键词：TRPV4; anti-influenza; machine learning; repurposing drugs; molecular docking
-
Taurolidine inhibits influenza virus infection and prevents influenza-induced cytokine storm, vasoconstriction and lung damage
作者：Lv, Chaoxiang;Lv, Chaoxiang;Guo, Jin;Luo, Rongbo;Li, Yuanguo;Qian, Bingshuo;Wang, Tiecheng;Shen, Beilei;Sun, Weiyang;Gao, Yuwei;Lv, Chaoxiang;Guo, Jin;Gao, Yuwei;Qian, Bingshuo;Zou, Xiaopan;Gao, Yuwei
关键词：Taurolidine; Vasoconstriction; Influenza virus; Calcium influx; MLCK/p-MLC signaling pathway
-
Progress in combination vaccines and the co-administration of influenza virus and SARS-CoV-2 vaccines
作者：Hu, Chengyu;Niu, Chenguang;Li, Xiaohui;Wei, Qiannan;Ren, Zhiguang;Li, Xiaodong;He, Ke;Li, Mengyu;Gao, Xiaonan;Ren, Zhiguang;Sun, Weiyang;Zhao, Yongkun;Li, Yuanguo;Xia, Xianzhu;Ren, Zhiguang;Wang, Tiecheng;Xia, Xianzhu;Wang, Tiecheng
关键词：SARS-CoV-2; influenza virus; coinfection; coadministration; combination vaccines
-
Plant U-box E3 ligase PpPUB59 regulates anthocyanin accumulation by ubiquitinating PpBBX24 in 'Zaosu' pear and its red bud mutation
作者：Li, Shuran;Li, He;Li, Shuran;Ou, Chunqing;Liu, Xiaofeng;Wang, Fei;Zhang, Yanjie;Qi, Liyong;Jiang, Shuling
关键词：PpPUB59; Ubiquitination; Anthocyanin; Pear
