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Gut Lactococcus garvieae promotes protective immunity to foodborne Clostridium perfringens infection

文献类型： 外文期刊

作者： Wang, Xue-Yin 1 ; Meng, Fan-Hua 1 ; Zhang, Ming-Yue 1 ; Li, Fen-Xin 1 ; Lei, Yu-Xin 1 ; Ma, Zhao-Guo 1 ; Li, Jia-Qi 1 ; Lou, Ya-Nan 1 ; Chu, Yue-Feng 2 ; Ma, Ke 2 ; Yu, Shui-Xing 1 ;

作者机构： 1.Inner Mongolia Univ, State Key Lab Reprod Regulat & Breeding Grassland, Coll Life Sci, Hohhot, Peoples R China

2.Lanzhou Univ, Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Coll Vet Med,Lanzhou Vet Res Inst, Lanzhou, Peoples R China

3.Inner Mongolia Univ, Coll Life Sci, Inner Mongolia Engn Technol Res Ctr Germplasm Reso, Hohhot, Peoples R China

关键词： probiotics; Lactococcus garvieae; intestinal mucosal barrier; Clostridium perfringens; enterocolitis

期刊名称：MICROBIOLOGY SPECTRUM （ 影响因子：3.7； 五年影响因子：4.2 ）

ISSN： 2165-0497

年卷期： 2024 年

页码：

收录情况： SCI

摘要： The gut microbiota, a pivotal component of the intestinal mucosal barrier, is critical for host resistance to enteric pathogen infection. Here, we report a novel function of the potentially probiotic Lactococcus garvieae strain LG1 (L. garvieae strain LG1) in maintaining intestinal mucosal barrier integrity and protecting against foodborne Clostridium perfringens (C. perfringens) infection. L. garvieae was isolated from the intestinal contents of Chinese Mongolian sheep (MS) and exhibited potential probiotic properties. In a C. perfringens enterocolitis model, L. garvieae-pretreated mice were less susceptible to C. perfringens infection compared with Phosphate buffered solution (PBS)-pretreated mice, which manifested as higher survival rates, lower pathogen loads, less weight loss, mild clinical symptoms and intestinal damage, and minor inflammation. Further mechanistic analysis showed that L. garvieae could ameliorate the disruption of intestinal permeability and maintain the integrity of the intestinal mucosal barrier by promoting the expression of tight junction proteins and mucoproteins. Moreover, L. garvieae was also able to facilitate antimicrobial peptide expression and ameliorate dysbiosis of the gut microbiota caused by C. perfringens. Together, these findings highlight the prospect of immunomodulatory potentially probiotic L. garvieae and might offer valuable strategies for prophylaxis and/or treatment of pathogenic C. perfringens mucosal infection.

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