Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus
文献类型： 外文期刊
作者： Zhi, Feijie 1 ; Liu, Kemeng 1 ; Geng, Hao 1 ; Su, Mengru 1 ; Xu, Jian 1 ; Fu, Lei 1 ; Ma, Ke 1 ; Gao, Pengcheng 1 ; Yuan, Lvfeng 1 ; Chu, YueFeng 1 ;
作者机构： 1.Lanzhou Univ, Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Coll Vet Med,State Key Lab Anim Dis Control & Prev, Lanzhou 730000, Peoples R China
2.Gansu Prov Res Ctr Basic Disciplines Pathogen Biol, Lanzhou 730046, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Vet Etiol Biol, Key Lab Ruminant Dis Prevent & Control West, Lanzhou, Peoples R China
关键词： Brucella; ArsR; T4SS; VjbR; virulence
期刊名称：EMERGING MICROBES & INFECTIONS （ 影响因子：7.5； 五年影响因子：7.2 ）
ISSN：
年卷期： 2024 年 13 卷 1 期
页码：
收录情况： SCI
摘要： Brucellosis, caused by the intracellular pathogen Brucella, is a major zoonotic infection that promotes reproductive disease in domestic animals and chronic debilitating conditions in humans. The ArsR family of transcriptional regulators plays key roles in diverse cellular processes, including metal ion homeostasis, responding to adverse conditions, and virulence. However, little is known about the function of ArsR family members in Brucella. Here, we identified ArsR2 as a nonclassical member of the family that lacks autoregulatory function, but which nevertheless plays a vital role in maintaining copper homeostasis in B. abortus. ArsR2 is a global regulator of 241 genes, including those involved in the VirB type IV secretion system (T4SS). Significantly, ArsR2 regulates T4SS production in B. abortus by targeting VjbR which encodes a LuxR-type family transcriptional regulator. Moreover, copper modulates transcriptional activity of ArsR2, but not of VjbR. Furthermore, deletion of arsR2 attenuated virulence in a mouse model. Collectively, these findings enhance understanding of the mechanism by which ArsR proteins regulate virulence gene expression in pathogenic Brucella species.
- 相关文献
作者其他论文 更多>>
-
Application of multi-omics technology in pathogen identification and resistance gene screening of sheep pneumonia
作者：Huang, Kai;Li, Xiaolong;Xu, Dan;Tian, Huibin;Li, Fadi;Wang, Weimin;Huang, Kai;Li, Xiaolong;Xu, Dan;Tian, Huibin;Li, Fadi;Wang, Weimin;Huang, Kai;Li, Xiaolong;Xu, Dan;Tian, Huibin;Li, Fadi;Wang, Weimin;Yuan, Lvfeng;Liu, Jia;Zhang, Xiaoxue;Peng, Jie
关键词：Sheep; Multi-omics; Pathogen identification;
Mycoplasma ovipneumoniae ; Genome-wide association study; Disease-resistant breeding -
Genome mining, synthesis, antibacterial mechanism, and application of the gut commensal-derived antibacterial peptide CR24
作者：Ma, Ke;Ran, Wei;Chu, Xin-long;Fu, Lei;Gao, Peng-cheng;Li, Xue-rui;Zhi, Fei-jie;Song, Yin-juan;Chu, Yue-feng;Ma, Ke;Ran, Wei;Chu, Xin-long;Fu, Lei;Gao, Peng-cheng;Li, Xue-rui;Zhi, Fei-jie;Song, Yin-juan;Chu, Yue-feng;Ma, Ke;Ran, Wei;Chu, Xin-long;Fu, Lei;Gao, Peng-cheng;Li, Xue-rui;Zhi, Fei-jie;Song, Yin-juan;Chu, Yue-feng;Zhang, Jian-gang;Yang, Yong-jun
关键词：Gut commensal; Bacillus haynesii; CR24; Antibacterial activity; Mode of action
-
A novel pilus-associated gene cluster is implicated in Streptococcus agalactiae virulence
作者：Xu, Wanyou;Lu, Qiangsheng;Tian, Meijuan;Song, Yangming;Zeng, Qiaoying;Peng, Jie;Yuan, Lvfeng;Yuan, Lvfeng
关键词：
Streptococcus agalactiae ; adhesion; pilus-related genes; pathogenicity -
Mycoplasma ovipnuemoniae impairs the immune response of sheep and suppresses neutrophil function by inhibiting S100A9
作者：Yan, Chenbo;Dong, Tianning;Zhao, Bingru;Yang, Hua;Cai, Yu;Li, Shanglai;Liu, Maojun;Zhang, Yanli;Shan, Yiyi;Cheng, Zilong;Liu, Maojun;Liu, Qiuyue;Chu, Yuefeng;Hao, Huafang
关键词：Sheep; Mycoplasma ovipneumoniae; ScRNA-seq; Neutrophils
-
DNA Subunit Vaccine and Recombinant BCG Based on Mycobacterial Lipoprotein LprO Enhance Anti-Tuberculosis Protection in the Lungs of Mice
作者：Huang, Weili;Xu, Shuqin;Shen, Lifang;Chen, Dan;Liu, Hanmei;Tang, Yuting;Xiao, Wenxuan;Zhou, Ziwei;Zhang, Shifeng;Li, Jixi;Zhang, Lu;Liu, Xiaolin;Fan, Xiaoyong;Fan, Xiaoyong;Chu, Yuefeng;Zhang, Lu;Zhang, Lu
关键词：tuberculosis; lipoprotein antigens; rBCG-lprO; DNA-lprO vaccine
-
Brucella osteoarthritis: recent progress and future directions
作者：Chen, Jinlei;Zhao, Guanghai;Song, Wei;Zhang, Haihong;Chen, Jinlei;Zhao, Guanghai;Song, Wei;Zhang, Haihong;Chen, Jinlei;Zhi, Feijie;Su, Mengru;Geng, Hao;Chu, Yuefeng;Chen, Jinlei;Zhi, Feijie;Su, Mengru;Geng, Hao;Chu, Yuefeng;Chen, Jinlei;Zhi, Feijie;Su, Mengru;Geng, Hao;Chu, Yuefeng
关键词：osteoarthritis;
Brucella ; animal models; pathophysiological mechanisms; inflammation -
Selective Autophagy Mediated by Protein Ubiquitination in Major Prevalent Zoonoses
作者：Meng, Chi;Jiao, Fengyuan;Zhou, Gengxu;Wang, Lingjie;Wu, Shengping;Fan, Cailiang;Li, Jixiang;Cao, Liting;Zhou, Zuoyong;Jiao, Hanwei;Fan, Cailiang;Chu, Yuefeng
关键词：regulatory mechanisms; selective autophagy; ubiquitination modification; zoonotic diseases
