A novel pilus-associated gene cluster is implicated in Streptococcus agalactiae virulence
文献类型： 外文期刊
作者： Xu, Wanyou 1 ; Lu, Qiangsheng 1 ; Tian, Meijuan 1 ; Yuan, Lvfeng 2 ; Song, Yangming 1 ; Zeng, Qiaoying 1 ; Peng, Jie 1 ;
作者机构： 1.Gansu Agr Univ, Coll Vet Med, Lanzhou, Gansu, Peoples R China
2.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Lanzhou, Peoples R China
3.Lanzhou Univ, Coll Vet Med, State Key Lab Vet Etiol Biol, Lanzhou, Peoples R China
关键词：
期刊名称：VETERINARY RESEARCH （ 影响因子：3.5； 五年影响因子：4.0 ）
ISSN： 0928-4249
年卷期： 2025 年 56 卷 1 期
页码：
收录情况： SCI
摘要： Streptococcus agalactiae (S. agalactiae), also known as Group B Streptococcus (GBS), is an important zoonotic pathogen. It is an important pathogen that causes bovine mastitis and can also lead to severe infections in newborns, pregnant women, and individuals with a weakened immune system. Adhesion to host cells is the first critical step in S. agalactiae infection, making the identification of key adhesion-related genes essential for understanding the pathogenic mechanisms of GBS. In this study, we used the Tn transposon system to construct a mutant library of S. agalactiae A909 and employed the mouse mammary epithelial cell line EPH4-Ev as a model to screen and validate adhesion-related genes. Our results revealed a gene cluster containing BP, AP1, and SrtC. While these genes did not affect the basic biological characteristics of the bacteria, they significantly influenced the adhesion rate to cells and the virulence of A909 in mice. Further transcriptomic analysis revealed that the Tnfsf15 gene plays a critical role in the regulation of A909 strain pathogenicity mediated by the BP, AP1, and SrtC gene clusters during host infection.
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