文献类型： 外文期刊
作者： Meng, Chi 1 ; Jiao, Fengyuan 1 ; Zhou, Gengxu 1 ; Wang, Lingjie 1 ; Wu, Shengping 1 ; Fan, Cailiang 1 ; Li, Jixiang 1 ; Cao, Liting 1 ; Zhou, Zuoyong 1 ; Chu, Yuefeng 3 ; Jiao, Hanwei 1 ;
作者机构： 1.Southwest Univ, Coll Vet Med, Chongqing 402460, Peoples R China
2.Anim Epidem Prevent & Control Ctr Rongchang, Chongqing 402460, Peoples R China
3.Lanzhou Univ, Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Coll Vet Med,Lanzhou Vet Res Inst, Lanzhou 730000, Gansu, Peoples R China
关键词： regulatory mechanisms; selective autophagy; ubiquitination modification; zoonotic diseases
期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：3.0； 五年影响因子：3.4 ）
ISSN： 1865-1674
年卷期： 2025 年 2025 卷 1 期
页码：
收录情况： SCI
摘要： Zoonotic diseases not only cause great harm to animal health but also involve the development of animal husbandry, which in turn endangers human life and health and public health safety. Protein ubiquitination and autophagy are important ways for the body to degrade invading pathogens, which correspond to the ubiquitin (Ub)-proteasome system (UPS) and autophagic lysosomal pathway (ALP), respectively, and play an important role in the occurrence and development of diseases. For UPS, the substrate is delivered to the 26S proteasome system via a ubiquitination cascade and subsequently degraded and removed. For ALP, the substrate is encapsulated to form autophagosomes, which subsequently fuse with lysosomes to form autophagolysosomes, which are eventually degraded and cleared. However, a variety of zoonotic pathogens can interfere with the protein ubiquitination pathway and autophagy process to promote self-replication and survival, and resist host immune defense. This article reviews the mechanisms by which multiple pathogens interfere with protein degradation pathways, providing a new perspective for the treatment and prevention of zoonotic diseases.
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