Metabolic adaptations underlying evolution of Mycoplasma: Nucleotide metabolism and lipid modulation mechanisms driving growth and membrane fluidity in Mycoplasma bovis
文献类型： 外文期刊
作者： Li, Zhangcheng 1 ; Hao, Huafang 1 ; Cui, Wenjing 1 ; Chen, Shengli 1 ; Zhang, Ying 1 ; Chen, Rui 1 ; Baz, Ahmed Adel 1 ; Jin, Shanyu 1 ; Wang, Xueyan 1 ; Yan, Xinmin 1 ; Gao, Pengcheng 1 ; Xu, Lihua 5 ; Lan, Shimei 1 ; Chu, Yuefeng 1 ;
作者机构： 1.Lanzhou Univ, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Chinese Acad Agr Sci,Coll Vet Med, Lanzhou 730000, Peoples R China
2.Gansu Prov Res Ctr Basic Disciplines Pathogen Biol, Lanzhou 730046, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Anim Biosafety Risk Warning & Control Nort, Key Lab Ruminant Dis Prevent & Control West, Lanzhou 730046, Peoples R China
4.Shihezi Univ, Dept Anim Med, Shihezi 832003, Peoples R China
5.Ningxia Univ, Coll Anim Sci & Technol, Yinchuan 750021, Peoples R China
6.Xinjiang Agr Univ, Coll Vet Med, Urumqi 830052, Peoples R China
关键词： Multi-omics; Mycoplasma bovis; Genetic variation; Mycoplasmas metabolism; Lipidomic; DNA methylation
期刊名称：MICROBIOLOGICAL RESEARCH （ 影响因子：6.9； 五年影响因子：7.2 ）
ISSN： 0944-5013
年卷期： 2025 年 300 卷
页码：
收录情况： SCI
摘要： Pathogenic Mycoplasma is a critical pathogen responsible for plant, animal, and human diseases worldwide. Understanding its genetic characteristics and adaptive evolution is essential for elucidating the related transmission mechanisms and pathogenicity. However, analysing the genetic evolution of Mycoplasma solely at the genome level provides an incomplete understanding of the biological characteristics driven by genetic variation. In this study, Mycoplasma bovis (M. bovis), a pathogen of ruminants, was used as a model organism. A multi-omics approach was employed to perform a comprehensive comparative analysis of the globally prevalent genotype ST52 strain and a novel genotype strain derived from it, which exhibited distinct biological phenotypes. The results demonstrated that the enhanced activity of the nucleotide metabolic pathways in M. bovis support its rapid proliferation during the logarithmic growth phase. Additionally, M. bovis regulates its cell membrane fluidity and enhances its adaptability to osmotic stress through modulation of lysophospholipid content. A novel protein with phospholipase activity, MB0331, was identified and found to enhance membrane fluidity and adaptability to high-glucose environments in M. bovis. MB0331 homologous proteins are widely present in other mycoplasma species. The active nucleotide and lipid metabolic pathways in the novel genotype strain may be correlated with abundant DNA methylation in the gene body. This comprehensive multi-omics analysis advances our understanding of the adaptive evolution of M. bovis and provides new insights and evidence to inform future studies regarding environmental adaptability and genetic variation mechanisms in Mycoplasma.
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