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Comparative analysis of the genetic diversity of the neutral microsatellite loci and second exon of the goat MHC-DQB1 gene

文献类型： 外文期刊

作者： Gong, Ying 1 ; Guo, Yi 1 ; He, Yong-Meng 1 ; Yuan, Ying 1 ; Yang, Bai-Gao 1 ; Duan, Xing-Hai 1 ; Liu, Cheng-Li 1 ; Zhang, 1 ;

作者机构： 1.Southwest Univ, Coll Anim Sci & Technol, Chongqing Engn Res Ctr Herbivores Resource Protec, Chongqing Key Lab Forage & Herbivore, 2 Tiansheng Rd, Chongqing 400715, Peoples R China

2.Yunnan Anim Sci & Vet Inst, Kunming, Yunnan, Peoples R China

3.Chinese Acad Agr Sci CAAS, Inst Anim Sci, Beijing, Peoples R China

关键词： Major histocompatibility complex (MHC); microsatellite markers; goats; genetic diversity; selection

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.271； 五年影响因子：1.697 ）

ISSN： 1049-5398

年卷期：

页码：

收录情况： SCI

摘要： This study compared and analyzed the genetic diversity and population structure of exon 2 of the DQB1 gene and 13 autosomal neutral microsatellite markers from 14 Chinese goat breeds to explore the potential evolutionary mechanism of the major histocompatibility complex (MHC). A total of 287 haplotypes were constructed from MHC-DQB1 exon 2 from 14 populations, and 82 nucleotide polymorphic sites (SNPs, 31.78%) and 172 heterozygous individuals (79.12%) were identified. The F-ST values of the microsatellites and MHC-DQB ranged between 0.01831-0.26907 and 0.00892-0.38871, respectively. Furthermore, 14 goat populations showed rich genetic diversity in the microsatellite loci and MHC-DQB1 exon 2. However, the population structure and phylogenetic relationship represented by the two markers were different. Positive selection and Tajima's D test results showed the occurrence of a diversified selection mechanism, which was primarily based on a positive and balancing selection in goat DQB. This study also found that the DQB sequences of bovines exhibited trans-species polymorphism (TSP) among species and families. In brief, this study indicated that positive and balancing selection played a major role in maintaining the genetic diversity of DQB, and TSP of MHC in bovines was common, which enhanced the understanding of the MHC evolution.

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