文献类型： 外文期刊
作者： Zhang, Yingpeng 1 ; Li, Xingxing 1 ; Yang, Yunshang 1 ; Teng, Zhidong 2 ;
作者机构： 1.Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou 730050, Peoples R China
2.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Lanzhou 730046, Peoples R China
关键词： hydrazine; pyrazole derivative; intramolecular charge transfer; visual detection; fluorescent probe
期刊名称：CHINESE JOURNAL OF INORGANIC CHEMISTRY （ 影响因子：0.7； 五年影响因子：0.5 ）
ISSN： 1001-4861
年卷期： 2025 年 41 卷 7 期
页码：
收录情况： SCI
摘要： A fluorescence quenching probe (THI) for visually detecting hydrazine (N2H4) was synthesized and char- acterized by Knoevenagel condensation reaction using pyrazole derivatives as fluorescent groups. Spectroscopic studies revealed that, under optimal excitation and emission wavelengths, the THI exhibited high selectivity and sen- sitivity toward N2H4, maintaining excellent anti-interference performance even in the presence of various analytes. Additionally, the THI demonstrated ultrafast response time (18 s), attributed to the efficient nucleophilic addition reaction between its optimized molecular recognition site and N2H4. The detection limit for N2H4 was determined to be 0.141 mu mol L-1, meeting the requirements for trace-level analysis. The detection mechanism, verified by mass spectrometry and density functional theory calculations, is ascribed to N2H4-induced intramolecular charge transfer (ICT), leading to fluorescence quenching. Furthermore, THI was successfully fabricated into test strips for the quan- titative detection of N2H4 and applied for fluorescence imaging of N2H4 in HeLa cells.
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