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Skin transcriptome analysis identifies the key genes underlying fur development in Chinese Tan sheep in the birth and Er-mao periods

文献类型： 外文期刊

作者： Li, Ya Chao 1 ; He, Dong Qian 1 ; Ma, Yue Hui 2 ; Ma, Qin 3 ; Ding, Wei 3 ; Chen, Yong Hong 1 ; Zhang, Meng 1 ; Luo, Fang 1 ; Chen, Li Yao 1 ; Wang, Jun Kui 1 ; Jiang, Lin 2 ; Li, Ying Kang 3 ; Tao, Jin Zhong 1 ;

作者机构： 1.Ning Xia Univ, Coll Agr, Yin Chuan 750021, Peoples R China

2.Chinese Acad Agr Sci CAAS, Inst Anim Sci IAS, Key Lab Farm Anim Genet Resources & Utilizat, Minist Agr China, Beijing 100193, Peoples R China

3.Anim Sci Inst Ning Xia Agr & Forestry Acad, Yin Chuan 750002, Peoples R China

关键词： FOS; Hair follicle development; RNA-seq; H; E staining; Differential expression

期刊名称：GENE （ 影响因子：3.913； 五年影响因子：3.48 ）

ISSN： 0378-1119

年卷期： 2022 年 820 卷

页码：

收录情况： SCI

摘要： Hair follicle development in Tan sheep differs significantly between the birth and Er-mao periods, but the underlying molecular mechanism is still unclear. We profiled the skin transcriptomes of Tan sheep in the birth and Er-mao periods via RNA-seq technology. The Tan sheep examined consisted of three sheep in the birth period and three sheep in the Er-mao period. A total of 364 differentially expressed genes (DEGs) in the skin of Tan sheep between the birth period and the Er-mao period were identified, among which 168 were upregulated and 196 were downregulated. Interestingly, the FOS proto-oncogene (FOS) (fold change = 22.67, P value = 2.15*10(boolean AND)44) was the most significantly differentially expressed gene. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found that the FOS gene was significantly enriched in the signaling pathway related to hair follicle development. Immunohistochemical analysis showed that the FOS gene was expressed in the skin of Chinese Tan sheep at the birth and Er-mao periods, with significantly higher expression in the Er-mao period. Our findings suggest that the FOS gene promotes hair follicle development in Tan sheep.

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