Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway
文献类型： 外文期刊
作者： Yang, Chun 1 ; Sun, Shengnan 1 ; Zhang, Qi 1 ; Guo, Jia 1 ; Wu, Tengfei 3 ; Liu, Ying 1 ; Yang, Min 1 ; Zhang, Yan 4 ; Peng, 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, Changchun, Peoples R China
2.State Key Lab Mol Biol Special Econ Anim, Changchun, Peoples R China
3.China Med Univ, Dept Lab Anim Sci, Shenyang, Peoples R China
4.Acad Mil Med Sci, Inst Mil Vet, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun, Peoples R China
期刊名称：STEM CELLS INTERNATIONAL （ 影响因子：5.443； 五年影响因子：5.305 ）
ISSN： 1687-966X
年卷期： 2020 年 2020 卷
页码：
收录情况： SCI
摘要： Postoperative cognitive dysfunction (POCD) is a severe complication of cardiopulmonary bypass (CPB) and has common characteristics such as acute cognitive dysfunction, impaired memory, and inattention. Mesenchymal stem cells (MSCs) are multipotent cells that have therapeutic potentials mainly through paracrine action via secreting growth factors and cytokines. Exosomes are one of the important paracrine factors and have been reported as potential cell-free therapy for the treatment of autoimmune and central nervous system disorders. In this study, we examined exosomes derived from antler MSCs (AMSCs) of POCD rats after CPB and evaluated their potential regulatory mechanisms. AMSC-derived exosomes reduced neurological damage and brain damage and prevent apoptosis in CPB rats. Furthermore, AMSC-derived exosomes were found to reduce hippocampal neuronal apoptosis and the expression of TLR2, TLR4, MyD88, and NF-kappa B in CPB rats. However, the above effects of AMSC-derived exosomes on CPB rats were abolished partially by toll-like receptor 2/4 (TLR2/TLR4) agonist (LPS-EB). In conclusion, AMSC-derived exosomes can improve cognitive function in CPB rats through inhibiting the TLR2/TLR4 signaling pathway.
- 相关文献
作者其他论文 更多>>
-
Development of an enhanced hybrid attention YOLOv8s small object detection method for phenotypic analysis of root nodules
作者：Zhao, Ya;Zhang, Wen;Zhang, Liangxiao;Tang, Xiaoqian;Wang, Du;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Zhao, Ya;Li, Peiwu
关键词：Root nodules; YOLOv8s; Hybrid attention mechanism; Small object detection; Phenotypic characteristics
-
Smartphone-assisted electrochemiluminescence imaging test strips towards dual-signal visualized and sensitive monitoring of aflatoxin B1 in corn samples
作者：Chen, Miao-Miao;Jiang, Jun;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Chen, Miao-Miao;Jiang, Jun;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Chen, Miao-Miao;Zhang, Min-Ling;Song, Xiao;Zhang, Xiuhua;Chen, Miao-Miao;Song, Xiao
关键词：Electrochemiluminescence imaging; Test strips; Nanomaterials; Dual-signal outputs; Aflatoxin B1; Food safety
-
Influence of the 'painless' TRP channel on temperature-dependent escape and humidity-related pupation in Bactrocera dorsalis larvae
作者：Zhang, Yan;Zhang, Panpan;Luo, Zhicai;Wang, Qi;Zhang, Jie;Yang, Minghuan;Yan, Shanchun;Liu, Wei;Wang, Guirong
关键词：Bactrocera dorsalis; Bdorpainless; CRISPR/Cas9; extreme environments; escape behavior
-
Estimation of Processing Tomato Nutrient Uptake Based on the QUEFTS Model in Xinjiang
作者：Yibati, Halihashi;Gao, Jie;Yibati, Halihashi;Zhang, Yan;Li, Qingjun;Xu, Xinpeng;He, Ping;Yin, Xinhua
关键词：processing tomato; fruit yield; QUEFTS model; nutrient; internal efficiency (IE)
-
Dual-channel microfluidic paper-based fluorescent immunosensor for simultaneous detection of aflatoxin B1 and capsaicin in edible oils
作者：Girmatsion, Mogos;Tang, Xiaoqian;Zhang, Qi;Wu, Wenqin;Hu, Xiaofeng;Li, Peiwu;Girmatsion, Mogos;Tang, Xiaoqian;Zhang, Qi;Wu, Wenqin;Hu, Xiaofeng;Li, Peiwu;Girmatsion, Mogos;Tang, Xiaoqian;Zhang, Qi;Wu, Wenqin;Hu, Xiaofeng;Li, Peiwu;Girmatsion, Mogos;Tang, Xiaoqian;Zhang, Qi;Wu, Wenqin;Hu, Xiaofeng;Li, Peiwu;Girmatsion, Mogos;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Girmatsion, Mogos;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Girmatsion, Mogos;Zhang, Qi;Li, Peiwu;Girmatsion, Mogos
关键词：Dual-channel paper device; Immunosensor; Phycocyanin; Aflatoxin B 1; Capsaicin; Edible oils
-
Single-cell RNA sequencing of the spleen reveals differences in Salmonella typhimurium infection mechanisms between different chicken breeds
作者：Zhang, Qi;Wang, Qiao;Zheng, Jumei;Zhang, Jin;Zhang, Gaomeng;Wen, Jie;Li, Qinghe;Zhao, Guiping;Ying, Fan;Liu, Dawei
关键词：Chicken; Disease resistance; Single-cell RNA sequencing; Bacterial infection; CD45+cells
-
CsCBF1/CsZHD9-CsMADS27, a critical gene module controlling dormancy and bud break in tea plants
作者：Hao, Xinyuan;Tang, Junwei;Chen, Yao;Huang, Chao;Zhang, Weifu;Liu, Ying;Wang, Lu;Ding, Changqing;Yang, Yajun;Wang, Xinchao;Chen, Yao;Yue, Chuan;Liu, Ying;Dai, Wenhao;Horvath, David P.
关键词：bud dormancy; bud break; MADS-box; gene function; regulatory network;
Camellia sinensis
