Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems
文献类型： 外文期刊
作者： Qian, Le 1 ; Qi, Suzhen 2 ; Wang, Zhao 3 ; Magnuson, Jason T. 4 ; Volz, David C. 4 ; Schlenk, Daniel 4 ; Jiang, Jiazhe 1 ;
作者机构： 1.China Agr Univ, Coll Sci, 2 Yuan Ming Yuan West Rd, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, Inst Agr Res, Risk Assessment Lab Bee Prod Qual & Safety, Minist Agr, Beijing, Peoples R China
3.Jilin Acad Agr Sci, Inst Plant Protect, Jilin, Jilin, Peoples R China
4.Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA
关键词： Boscalid; Neurobehavioral response; RNA sequencing; Visual system; Nervous system
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）
ISSN： 0304-3894
年卷期： 2021 年 404 卷
页码：
收录情况： SCI
摘要： Boscalid is a persistent fungicide that is frequently detected in surface waters and may be neurotoxic to aquatic organisms. Herein, we evaluated the effects of environmentally relevant boscalid concentrations to zebrafish to explore its potentially neurotoxic mechanisms of effect. Behavioral responses (swimming, phototaxis, and predation), histopathology, transcriptomics, biochemical parameter analysis and gene expression of larval and adult zebrafish following boscalid treatment were assessed. We found that boscalid significantly inhibited the locomotor ability and phototactic response of larvae after an 8-d exposure, and altered the locomotor activity, predation trajectories and ability in adults after a 21-d exposure. It was noted that predation rates of zebrafish were significantly decreased by 30% and 100% after exposure to 0.1 and 1.0 mg/L boscalid, respectively. Adverse alterations in the cell differentiation of eyes and brain injury were also observed in both larvae and adults following boscalid exposure. The expression of genes related to neurodevelopment, neurotransmission, eye development, and visual function, in conjunction with RNA-Seq results, indicated that boscalid may impair visual phototransduction and nervous system processes in larval zebrafish. Conclusively, boscalid exposure may affect the neurobehavioral response of zebrafish by impairing proper visual and nervous system function.
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