Novel neonicotinoid insecticide cycloxaprid exhibits sublethal toxicity to honeybee (Apis mellifera L.) workers by disturbing olfactory sensitivity and energy metabolism
文献类型： 外文期刊
作者： Zhang, Wei 1 ; Jiang, Zhiyang 1 ; Ding, Mu 2 ; Wang, Xue 2 ; Huang, Aidi 2 ; Qiu, Lihong 1 ; Qi, Suzhen 2 ;
作者机构： 1.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, State Key Lab Resource Insects, Inst Apicultural Res, Beijing 100093, Peoples R China
3.Beijing Univ Agr, Beijing 100096, Peoples R China
关键词： Non-target organisms; Pesticides; Behavior; Proboscis extension reflex; Odorant-binding protein
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）
ISSN： 0304-3894
年卷期： 2025 年 485 卷
页码：
收录情况： SCI
摘要： The risk of neonicotinoid insecticides to honeybees is a global issue. Cycloxaprid (CYC) is a novel neonicotinoid insecticide with outstanding activities, good safety profiles, and no cross-resistance with other neonicotinoids. Information on the environmental risks of CYC is limited, especially its effects on honeybees. Herein, the acute and chronic toxicities of CYC on honeybees were evaluated, and the underlying mechanisms were explored via transcriptomics and molecular docking. The results indicate that CYC had high toxicity to honeybees, with a 48-h oral median lethal dose of 32.8 ng/bee. Over a 10-days of chronic exposure to CYC at sublethal concentration 30 mu g/L, the honeybees showed significantly decreased survival rates and food consumption. Additionally, the sensitivity of honeybees to sucrose and odors and CO2 production was significantly reduced. Furthermore, molecular docking revealed that CYC has higher binding affinity than odors to odorant-binding proteins, and the olfactory and metabolism pathways gene expression was negatively affected at transcriptome level. These findings indicate that CYC at sublethal concentration can pose risks to honeybees by affecting their olfactory function and energy metabolic balance. Further study and consideration are needed to fully exploit the benefits of this pesticide.
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