Heat-Inactivated Lactiplantibacillus plantarum FRT4 Alleviates Diet-Induced Obesity via Gut-Liver Axis Reprogramming
文献类型： 外文期刊
作者： Huang, Yuyin 1 ; Wang, Qingya 2 ; Han, Xiling 2 ; Meng, Kun 1 ; Liu, Guohua 1 ; Zhang, Haiou 1 ; Zhang, Rui 2 ; Cai, Hongying 1 ; Yang, Peilong 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Feed Res, Key Lab Feed Biotechnol, Minist Agr & Rural Affairs, Beijing 100081, Peoples R China
2.Yunnan Normal Univ, Key Lab Yunnan Biomass Energy & Biotechnol Environ, Kunming 650500, Peoples R China
关键词：
期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN：
年卷期： 2025 年 14 卷 16 期
页码：
收录情况： SCI
摘要： Obesity and related metabolic disorders are major global health challenges. Postbiotics, such as heat-inactivated probiotics, have attracted attention for their improved safety, stability, and potential metabolic benefits compared to live probiotics. However, the comparative anti-obesity effects and mechanisms of live versus heat-inactivated Lactiplantibacillus plantarum FRT4 remain unclear, so this study systematically evaluated their effects and mechanisms in high-fat-diet-induced obese mice. Mice received oral administration of live or heat-inactivated FRT4 (prepared by heating in a water bath at 80 degrees C for 5 min) for 16 weeks. Comprehensive analyses included metabolic profiling, histological evaluation, serum and liver biomarkers, gut microbiota composition, liver metabolomics, and transcriptomics. Both live and inactivated FRT4 significantly reduced body weight gain, adiposity, hepatic steatosis, and dyslipidemia, with inactivated FRT4 exhibiting comparable or superior efficacy. Notably, inactivated FRT4 restored gut microbiota composition, increased short-chain fatty acid production, and regulated hepatic metabolic pathways. Multi-omics analyses revealed modulation of lipid biosynthesis, amino acid metabolism, and energy utilization pathways. Specifically, the "biosynthesis of unsaturated fatty acids" pathway was downregulated in metabolomics and significantly enriched in transcriptomics, highlighting its central role in FRT4M-mediated metabolic reprogramming. These findings demonstrate that heat-inactivated Lp. plantarum FRT4 exerts systemic anti-obesity effects via gut-liver axis modulation, supporting its potential as a promising postbiotic intervention for obesity and metabolic dysfunction.
- 相关文献
作者其他论文 更多>>
-
Comprehensive analysis of the transcriptome-wide m6A Methylome in sheep testicular development
作者：Xi, Binpeng;Lu, Zengkui;Zhang, Rui;Li, Jianye;An, Xuejiao;Yue, Yaojing;Xi, Binpeng;Lu, Zengkui;Zhang, Rui;Li, Jianye;An, Xuejiao;Yue, Yaojing;Xi, Binpeng;Zhao, Shengguo
关键词：mRNA m6A methylation; Testicular development; F1 hybrid of Southdown x Hu sheep; Spermatogenesis
-
Effects of Lactobacillus acidophilus on production performance and immunity of broiler chickens and their mechanism
作者：Liu, Jinmei;Gu, Hongxia;Jia, Rui;Li, Shuzhen;Chen, Zhimin;Zheng, Aijuan;Chang, Wenhuan;Liu, Guohua
关键词：Lactobacillus acidophilus; broiler chicken; growth performance; carcass characteristics; immunity
-
Metagenomic investigation of bacterial laccases in a straw-amended soil
作者：Yu, Dali;Liu, Ying;Yu, Dali;Cai, Hongying;Huang, Wanqiu;Yang, Peilong;Wu, Huijun
关键词：Bacterial laccase; Metagenomics; Straw-amended soil; Profile hidden Markov models
-
The potential of Trichoderma asperellum for degrading wheat straw and its key genes in lignocellulose degradation
作者：Zhu, Qijun;Liu, Weiwei;Song, Liye;Han, Yunsheng;Cai, Hongying;Yang, Peilong;Meng, Kun;Guo, Zhenzhen;Bian, Zhiyao
关键词：wheat straw; lignocellulose degradation; enzymatic activity; transcriptome; reducing sugars;
Trichoderma asperellum -
Transcriptome-Metabolome Analysis Reveals That Crossbreeding Improves Meat Quality in Hu Sheep and Their F1-Generation Sheep
作者：Zhang, Liwa;An, Xuejiao;Niu, Chune;Shi, Haina;Chen, Zhenghan;Zhang, Rui;Yue, Yaojing;Zhang, Liwa;An, Xuejiao;Niu, Chune;Shi, Haina;Chen, Zhenghan;Zhang, Rui;Yue, Yaojing;Zhang, Liwa;An, Xuejiao;Niu, Chune;Shi, Haina;Chen, Zhenghan;Zhang, Rui;Yue, Yaojing;Xu, Zhenfei;Geng, Zhiguang;Zhang, Jinxia
关键词：crossbreed; longissimus dorsi; meat quality; transcriptomics; metabolomics
-
CRISPR-Cas9-mediated knockout of OsKCS11 in rice reveals potential crosstalk between very-long-chain fatty acids and cytokinin
作者：Zhou, Jianping;Guo, Yachong;Wang, Yibo;Yang, Hongjun;Wang, Wei;Fu, Xinxuan;Zhang, Rui;Zhang, Yong;Pang, Rui;Wang, Quan;Han, Yangshuo;Zheng, Xuelian;Zhang, Yong;Han, Yangshuo;Zhang, Tao
关键词：very-long-chain fatty acid; beta-ketoacyl-CoA synthase; CRISPR-Cas9; acetyl-CoA; cytokinin; rice
-
The investigation into the physicochemical properties of fermented soybean meal and its effects as a substitute for soybean meal on the growth performance and intestinal development of broiler chickens
作者：Zhao, Manqi;Chen, Xing;Liu, Guohua;Chen, Zhimin;Yang, Peilong;Meng, Kun;Zheng, Aijuan;Li, Shuang
关键词：Fermented soybean meal; Amino acid content; Peptide relative molecular weight; Anti-nutritional factors; Intestinal morphology; Fermented soybean meal; Amino acid content; Peptide relative molecular weight; Anti-nutritional factors; Intestinal morphology
